| Zugriffsnummer | 56797 |
| Dokumenttyp | Konferenzartikel |
| Sprache | Englisch |
| Titel | Frequency-resolved AC-susceptibility approach for MNPs detection in biomedical applications |
| Autor(in); Institution |
Barbieri, G.; Kiel-University, Kiel, GERMANY
Bangert, L.; Kiel-University, Kiel, GERMANY
Arbustini, J.; Kiel-University, Kiel, GERMANY
Gerken, M.; Kiel-University, Kiel, GERMANY
|
| Quelle/Jahr | Proceedings of the Workshop Biosignale 2026:(2026), 61 - 63 |
| ISBN | 978-3-99106-194-6 (online) |
| DOI | |
| Verlag | Innsbruck: Univ. Press |
| Konferenzangaben | Workshop Biosignale 2026, Innsbruck, 25-27, February, 2026, Austria |
| Freie Schlagworte | ACS frequency sweep ; gradiometer configuration ; magnetic nanoparticles |
| Zusammenfassung | Precise, non-invasive characterization of magnetic nanoparticles (MNPs) is key for biomedical applications such as targeted drug delivery and in-vivo protein monitoring. We present a portable and unshielded gradiometer setup capable of performing multi- frequency characterization of MNPs with the sample positioned outside the excitation and pick-up coils, employing an AC susceptibility approach. In addition to conventional in-coil characterization, the setup demonstrates reliable MNPs detection when a sample droplet is pumped and stopped near the sensing region at depths up to 10 mm. The proposed system allows a fast and wideband frequency sweep from 100 Hz to 10 kHz, keeping a low magnetic excitation field amplitude less than 0.5 mT and a total acquisition time of 8 minutes. The excitation and detection by a digital control architecture allows a customizable frequency scanning and a phase-sensitive signal demodulation. Validation was performed using micromod BNF-starch MNPs with a hydrodynamic diameter of 80 nm. The measured frequency-dependent response exhibited the expected dispersion behavior with a characteristic frequency of approximately 313 Hz. This work highlights the capability of the system to quantitatively characterize MNPs across a wide frequency range under realistic conditions at dch = 10mm from the sensor, potentially suitable for in-vivo-oriented frequency-resolved analysis. |
| Kostenfreier Zugang | Freier Zugang |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Barbieri, G., Bangert, L., Arbustini, J., Elzenheimer, E., Wiekhorst, F., Radon, P., & Gerken, M. (2026). Frequency-resolved AC-susceptibility approach for MNPs detection in biomedical applications. Workshop Biosignale 2026, Innsbruck, 25-27, February, 2026, Austria. https://doi.org/10.15203/99106-194-6-15