Zugriffsnummer 56079
Dokumenttyp Zeitschriftenartikel Open Access Gold
Peer Review mit Peer Review
Sprache Englisch
Titel High-intensity focused ultrasound sound pressure up to 100MPa based on a differential high bandwidth homodyne laser interferometer
Autor(in); Institution
Wang, Ke; National Institute of Metrology, Division of Mechanics and Acoustics, Beijing, CHINA
Xing, Guangzhen; National Institute of Metrology, Division of Mechanics and Acoustics, Beijing, CHINA
Song, Dan; Chongqing Medical University, State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing, CHINA
Wilkens, Volker; 1.6, Schall, PTB-Braunschweig
Yang, Ping; National Institute of Metrology, Division of Mechanics and Acoustics, Beijing, CHINA
Quelle/Jahr Optics Express: 34 (2026), 8, 15110 - 15123
Availability [online only]
ISSN 1094-4087
DOI
URL
Verlag Washington, DC: Optica
Zusammenfassung High-intensity focused ultrasound (HIFU) has emerged as a promising noninvasive technology for medical applications, including tumor ablation and targeted drug delivery, where precise control of acoustic pressure is critical. However, the traceable sound pressure amplitude, in the range of several megapascals, is much lower than the actual application of 100 megapascals, which compromises the metrological traceability and impedes clinical translation. In this study, we present a differential high-bandwidth homodyne laser interferometer designed for the accurate realization of HIFU acoustic pressure under treatment conditions. The system employs a four-channel detection scheme and a focused measurement beam to enhance its robustness against pellicle deflection and environmental disturbances. By integrating high-speed photodetection and a nonlinear error suppression algorithm based on arctangent demodulation, the system achieved a bandwidth of 500 MHz while maintaining high sensitivity. The experimental results demonstrated the successful measurement of HIFU pressures up to 124 MPa peak-to-peak, with a resolution better than 0.25 MPa. Comparative studies using a commercial heterodyne vibrometer (UHF-120) confirmed the accuracy and cost-effectiveness of the proposed homodyne system. This study provides a reliable and traceable method for high-pressure ultrasonic metrology, supporting the development and safety assurance of HIFU-based therapies.
Kostenfreier Zugang Open Access Gold
Rechteinformation https://doi.org/10.1364/OA_License_v2#VOR-OA
Themenbereich der Metrologie Akustik, Ultraschall, Beschleunigung
Innovationscluster Gesundheit ; Systemische Metrologie
Geschäftsfelder Grundlagen der Metrologie ; Metrologie für die Wirtschaft
Förderinformationen (1) Förderername: China
Förderprogramm: National Key Research and Development Program of China
Förderungsnummer: 2017YFF0205004
Förderinformationen (2) Förderername: National Natural Science Foundation of China
Förderungsnummer: 11904347
Förderinformationen (3) Förderername: National Institute of Metrology of China (NIM)
Förderungsnummer: AKYZD2401

Zitierung

Wang, K., Xing, G., Song, D., Wilkens, V., & Yang, P. (2026). High-intensity focused ultrasound sound pressure up to 100MPa based on a differential high bandwidth homodyne laser interferometer. Optics Express, 34(8), 15110–15123. https://doi.org/10.1364/OE.589341

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