Lambeng, Nora; Laboratoire National de Métrologie et D'Essais, Trappes, France
Douri, Sarah; Laboratoire National de Métrologie et D'Essais, Trappes, France
Chivas-Joly, Carine; Laboratoire National de Métrologie et D'Essais, Trappes, France
Alasonati, Enrica; Department of Biomedical and Inorganic Chemistry, Laboratoire National de Métrologie et D'Essais (LNE), Paris, FRANCE
de Carsalade du pont, Valentin; Department of Biomedical and Inorganic Chemistry, Laboratoire National de Métrologie et D'Essais (LNE), Paris, FRANCE
Sapalidis, Dimitrios; Center for X-ray Analytics, Empa, Swiss Federal Laboratories for Material Science and Technology, Lerchenfeldstr. 5, 9014 St. Gallen, Switzerland
Gerina, Marianna; Center for X-ray Analytics, Empa, Swiss Federal Laboratories for Material Science and Technology, Lerchenfeldstr. 5, 9014 St. Gallen, Switzerland
Silva, Bruno F. B.; Laboratory for Biointerfaces, Empa, St. Gallen, SWITZERLAND
Tache, Olivier; Université Paris-Saclay, Gif Sur Yvette, FRANCE
Lee, William A.; Chemical and Biological Sciences Department, National Physical Laboratory,Teddington, UK
Cant, David J. H.; Chemical and Biological Sciences Department, National Physical Laboratory,Teddington, UK
Minelli, Caterina; Chemical and Biological Sciences Department, National Physical Laboratory,Teddington, UK
Gollwitzer, Christian; 7.2, Röntgenmesstechnik mit Synchrotronstrahlung, PTB-Berlin
Schürmann, Robin; 7.2, Röntgenmesstechnik mit Synchrotronstrahlung, PTB-Berlin
Diaz Fernandez, Yuri Antonio; Department of Chemistry, University of Pavia, ITALY
The use of iron oxide nanoparticles as contrast agents for magnetic resonance imaging (MRI) poses key questions regarding accurate determination of particle size and chemical composition within micro-heterogeneous systems. Here we present the first systematic study on homogeneity for particle size and chemical composition on the nanoparticle-based MRI contrast agent FeraSpin™ R, combining complementary analytical tools across a multidisciplinary consortium, clustered around the EURAMET project MetrINo. Our results indicate that, depending on the target measurand, sizing methods can provide consistent values for the particle colloidal diameter and for the size of the particle core, independently of the effective volume of the sample probed. Conversely, the evaluation of homogeneity for chemical composition depends on the length-scale of the sampling, in agreement with Benedetti–Pichler description of multicomponent systems. This case study highlights the importance of measurement length-scale for comparison and integration of data from complementary analytical methods, opening new avenues for standardization to support regulatory positioning of emerging nanomedicines.>
Kostenfreier Zugang
Open Access Gold
Rechteinformation
CC BY 4.0 ; Creative Commons Attribution 4.0 License
Themenbereich der Metrologie
Photometrie und Radiometrie
Förderinformationen (1)
Förderername: European Partnership on Metrology
Förderer ID: 0000 0005 0727 0588
Förderer ID Typ: ISNI
Förderprogramm: 22HLT04 MetrINo
Zitierung
Maceratesi, V., Doveri, L. R., Engel, N., Cantoni, E., Pallavicini, P., Milanese, C., Sack, F., Gehrke, N., Briel, A., Lambeng, N., Douri, S., Chivas-Joly, C., Alasonati, E., de Carsalade du pont, V., Sapalidis, D., Gerina, M., Silva, B. F. B., Tache, O., Lee, W. A., Cant, D. J. H., Minelli, C., Gollwitzer, C., Schürmann, R., & Diaz Fernandez, Y. A. (2026). Effect of sampling volume on measurements of size and chemical homogeneity of MRI contrast agent FeraSpin™ R. Nanoscale Advances, 8(10), 3136–3150. https://doi.org/10.1039/d5na00463b
