| Zugriffsnummer | 55840 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Spatial signature of low-frequency network changes accounts for pallidal stimulation outcome in cervical dystonia |
| Autor(in); Institution |
Bahners, B. H.; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, GERMANY; Center for Movement Disorders and Neuromodulation, Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, GERMANY; Center for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women’s Hospital, Harvard Medical School, Boston, Massachusatts, USA
Lofredi, R.; Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt- Universität zu Berlin, GERMANY; Berlin Institute of Health, Berlin, GERMANY
Voss, H.; Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt- Universität zu Berlin, GERMANY
de Almeida Marcelino, A. L.; Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt- Universität zu Berlin, GERMANY
Goede, L. L.; Center for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women’s Hospital, Harvard Medical School, Boston, Massachusatts, USA; Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt- Universität zu Berlin, GERMANY
Feldmann, L. K.; Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt- Universität zu Berlin, GERMANY
Schnitzler, A.; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, GERMANY; Center for Movement Disorders and Neuromodulation, Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, GERMANY
Florin, E.; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, GERMANY
Kühn, A. A.; Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt- Universität zu Berlin, GERMANY; NeuroCure, Charité - Universitätsmedizin Berlin, Berlin, GERMANY; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Berlin, GERMANY
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| Quelle/Jahr | eBioMedicine: 124 (2026), 1 - 14 |
| Artikelnummer | 106140 |
| Availability | [online only] |
| ISSN | 2352-3964 (online) |
| DOI | |
| Verlag | Amsterdam [u.a.]: Elsevier BV |
| Freie Schlagworte | Magnetoencephalography ; Globus pallidus internus ; Electrophysiology effect mapping ; Network mapping ; Biomarker |
| Zusammenfassung | Background Pallidal deep brain stimulation (DBS) has remarkable effects in patients with cervical dystonia. Yet, its neurophysiological mechanisms are not fully resolved to date. Converging evidence suggests that pallidal DBS modulates sensorimotor and cerebellar network activity in dystonia, possibly by disrupting pathologically enhanced low-frequency oscillations in the basal ganglia. Still, anatomical and electrophysiological findings have rarely been linked, and it is unclear whether oscillatory changes occur in the same network identified in neuroimaging studies. Methods In this cross-sectional study, we investigate the effects of pallidal DBS in patients with cervical dystonia using magnetoencephalography recordings on and off stimulation. We correlated DBS outcomes to the whole-cortex pattern of DBS-induced power changes in each cortical vertex. Findings This analysis revealed a distinct low-frequency electrophysiological signature that accounted for significant amounts of variance in DBS improvements across the cohort. The signature was characterised by negative peaks within the supplementary motor area and the motor cortex as well as positive peaks in prefrontal and cerebellar areas. Interpretation Our study sheds light on the cortical and cerebellar effects of pallidal DBS on a whole-cortex level and puts emphasis on low-frequency power modulation as a mechanism of effective stimulation beyond the basal ganglia in patients with cervical dystonia. Our findings might inform DBS programming and targeting as well as non-invasive stimulation strategies in the future. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Bahners, B. H., Lofredi, R., Voss, H., de Almeida Marcelino, A. L., Goede, L. L., Feldmann, L. K., Schnitzler, A., Sander-Thömmes, T., Florin, E., & Kühn, A. A. (2026). Spatial signature of low-frequency network changes accounts for pallidal stimulation outcome in cervical dystonia. eBioMedicine, 124, 1–14. https://doi.org/10.1016/j.ebiom.2026.106140