| Zugriffsnummer | 55491 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Impact of adverse life experiences on pain, depression, anxiety, and comorbidities: a youth longitudinal sample |
| Autor(in); Institution |
Sperandio, Ginevra; Inserm U987 APHP, CHU Ambroise Paré, UVSQ, Paris-Saclay, Boulogne-Billancourt, FRANCE
Moliadze, Vera; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, GERMANY
Attal, Nadine; Inserm U987 APHP, CHU Ambroise Paré, UVSQ, Paris-Saclay, Boulogne-Billancourt, FRANCE
Bouhassira, Didier; Inserm U987 APHP, CHU Ambroise Paré, UVSQ, Paris-Saclay, Boulogne-Billancourt, FRANCE
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Barker, Gareth J.; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
Bokde, Arun L.W.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Desrivières, Sylvane; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, SGDP Centre, King's College London, London, United Kingdom
Grigis, Antoine; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Garavan, Hugh; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Gowland, Penny; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Heinz, Andreas; Department of Psychiatry and Psychotherapy CCM, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Brühl, Rüdiger; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, Jean-Luc; Institut National de la Santé et de la Recherche Médicale, INSERM U A10 “Trajectoires développementales en psychiatrie,” Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, FRANCE
Paillère Martinot, Marie-Laure; AP-HP, Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, FRANCE
Artiges, Eric; Psychiatry Department, EPS Barthélémy Durand, Etampes, FRANCE
Papadopoulos Orfanos, Dimitri; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Lemaitre, Herve; Institut des Maladies Neurodégénératives, UMR 5293, CNRS, CEA, Université de Bordeaux, Bordeaux, FRANCE
Paus, Tomáš; Departments of Psychiatry and Psychology, University of Toronto, Toronto, ON, CANADA
Poustka, Luise; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Hohmann, Sarah; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Millenet, Sabina; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Fröhner, Juliane H.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Smolka, Michael N.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Vaidya, Nilakshi; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Berlin, GERMANY
Walter, Henrik; Department of Psychiatry and Psychotherapy CCM, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Whelan, Robert; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, Gunter; Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Flor, Herta; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
|
| Quelle/Jahr | PAIN Reports: 11 (2026), 2, 1 - 11 |
| Artikelnummer | e1388 |
| Availability | [online only] |
| ISSN | 2471-2531 (online) |
| DOI | |
| URL | |
| Verlag | Riverwoods, IL: Wolters Kluwer Health |
| Freie Schlagworte | adverse life experiences ; anxiety ; comorbidity ; depression ; insula ; longitudinal study ; pain ; vulnerability |
| Zusammenfassung | Introduction: Exposure to adverse life experiences (ALEs) renders individuals vulnerable to the emergence of pain, depression, and anxiety. It remains unclear to what extent these symptom categories share common ALEs, especially in cases of comorbidity, and how these relationships manifest in developmental trajectories and neural pathways. Objectives: In this study, we investigated the impact of ALEs, considering their timing, quality, and quantity, as well as structural brain changes, on pain, depression, and anxiety symptoms, and their comorbidity from adolescence to young adulthood. Methods: We used prospective and retrospective questionnaires and magnetic resonance imaging data from a large European longitudinal cohort (N = 1700) spanning from 14 to 25 years. We conducted Latent-Class-Growth-Analysis for symptom levels of pain, depression, and anxiety, subsequent logistic regressions to explore prediction of ALEs on symptom classes, and mediation analysis to examine the role of insula in this association. Results: Physical illness unrelated to pain, bullying, and abuse-maltreatment were associated with pain; sexual abuse, bullying, parental violence, and deprivation with depression; bullying and deprivation with anxiety; substance abuse in the household and abuse-maltreatment with pain-depression comorbidity; deprivation with pain-anxiety comorbidity. Smaller insula volume in late adolescence was a significant mediator for the association between deprivation-related ALEs and the pain-anxiety, but not the pain-depression comorbidity. Conclusion: Together, although various and mainly different types of ALEs strongly impact pain, depression, and anxiety symptoms and their comorbidity, insula volume impacts are specific for pain-anxiety comorbidity. These findings may inform early screening and prevention for individuals affected by ALEs. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Förderinformationen (1) |
Förderername: European Commission (EC)
Förderer ID: 0000 0001 2242 8989 Förderer ID Typ: ISNI Förderprogramm: Horizon 2020 Framework Programme Titel der Förderung: Marie Sklodowska-Curie Förderungsnummer: grant agreement N 955684 |
Zitierung
Sperandio, G., Moliadze, V., Attal, N., Bouhassira, D., Banaschewski, T., Barker, G. J., Bokde, A. L., Desrivières, S., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Brühl, R., Martinot, J.-L., Paillère Martinot, M.-L., Artiges, E., Papadopoulos Orfanos, D., Lemaitre, H., Paus, T., Poustka, L., Hohmann, S., Millenet, S., Fröhner, J. H., Smolka, M. N., Vaidya, N., Walter, H., Whelan, R., Schumann, G., Flor, H., & Nees, F. (2026). Impact of adverse life experiences on pain, depression, anxiety, and comorbidities: a youth longitudinal sample. PAIN Reports, 11(2), 1–11. https://doi.org/10.1097/pr9.0000000000001388