Neurocognitive characterization of behaviour and mental illness through time-varying brain network analysis
Autor(in); Institution
Chang, Xiao; Institute of Science and Technology for Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Jia, Tianye; Institute of Science and Technology for Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Fu, Zening; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA
Xiang, Shitong; Institute of Science and Technology for Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Xia, Yunman; Institute of Science and Technology for Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Xie, Chao; Institute of Science and Technology for Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Zou, Jiyan; Institute of Science and Technology for Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Cao, Miao; Institute of Science and Technology for Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Zhang, Jie; Institute of Science and Technology for Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, Arun L. W.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IrelandMannheim, Heidelberg University, GERMANY
Desrivières, Sylvane; Social, Genetic, Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Flor, Herta; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Grigis, Antoine; NeuroSpin, CEA, Université Paris-Saclay, Gif-Sur-Yvette, FRANCE
Garavan, Hugh; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Gowland, Penny; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Heinz, Andreas; Department of Psychiatry and Psychotherapy, University of Tübingen, and German Center for Mental Health (DZPG), site Tübingen, GERMANY
Martinot, Jean-Luc; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales & psychiatrie", University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS, Gif-sur-Yvette, FRANCE
Martinot, Marie-Laure Paillère; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales & psychiatrie", University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS, Gif-sur-Yvette, FRANCE
Artiges, Eric; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales & psychiatrie", University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS, Gif-sur-Yvette, FRANCE
Nees, Frauke; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Papadopoulos Orfanos, Dimitri; NeuroSpin, CEA, Université Paris-Saclay, Gif-Sur-Yvette, FRANCE
Frouin, Vincent; NeuroSpin, CEA, Université Paris-Saclay, Gif-Sur-Yvette, FRANCE
Poustka, Luise; Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, GERMANY
Hohmann, Sarah; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Baeuchl, Christian; Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, GERMAY
Smolka, Michael N.; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, GERMANY
Vaidya, Nilakshi; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Walter, Henrik; Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Whelan, Robert; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Feng, Jianfeng; Institute of Science and Technology for Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Calhoun, Vince D.; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA
Schumann, Gunter; Centre for Population Neuroscience and Stratified Medicine (PONS), ISTBI, Fudan University, Shanghai, CHINA
Human cognitive processing involves dynamic interactions across brain regions, evolving over time. Traditional neuroimaging analysis often overlooks this temporal aspect, limiting insights into how functional network connectivity (FNC) supports ongoing cognition and behaviour. Using sliding window analysis, we captured FNC changes during tasks, reflecting network reconfiguration in cognitive processes. We further determined behavioural relevance of time-varying FNC by relating network measurements with task performances and psychopathology. We found that several whole-brain FNC patterns, or states, persist across resting and task-based fMRI, with state occurrences fluctuating with the most prominent task stimuli. Regional FNC distinguishes specific task conditions, and time-varying FNC explains more variance in psychopathology symptoms compared to static connectivity. These findings highlight that cognitive tasks reshape regional and whole-brain connectivity. By considering the different FNC states, time-varying connectivity provides a more comprehensive representation of brain interactions and thus may represent a better neural proxy for cognition and behaviour.
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Rechteinformation
CC BY 4.0 ; Creative Commons Attribution 4.0 License
Förderinformationen (1)
Förderername: National Natural Science Foundation of China
Förderer ID: 0000 0001 2107 957X
Förderer ID Typ: ISNI
Förderprogramm: 2023YFE0199700 to XC, 2019YFA0709502 to JF
Zitierung
Chang, X., Jia, T., Fu, Z., Xiang, S., Xia, Y., Xie, C., Zou, J., Cao, M., Zhang, J., Banaschewski, T., Bokde, A. L. W., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Brühl, R., Martinot, J.-L., Martinot, M.-L. P., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Frouin, V., Poustka, L., Hohmann, S., Baeuchl, C., Smolka, M. N., Vaidya, N., Walter, H., Whelan, R., Feng, J., Calhoun, V. D., & Schumann, G. (2026). Neurocognitive characterization of behaviour and mental illness through time-varying brain network analysis. Nature Communications, 17(1), 1–16. https://doi.org/10.1038/s41467-025-67398-w
