Neural and psychosocial signatures of the comorbidity between pain and affective symptoms
Autor(in); Institution
Scarlatti, Francesco; Department of Elderly Psychiatry and Neurostimulation, University Hospitals of Strasbourg, University of Strasbourg, Strasbourg, FRANCE; Department of Neuropsychology and Psychological Resilience Research, Research Group Learning and Brain Plasticity in Mental Disorders, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; UMR CNRS 7357, Engineering Science, Computer Science and Imaging Laboratory (ICube), University of Strasbourg, Strasbourg, FRANCE
Dormegny-Jeanjean, Ludovic; Department of Elderly Psychiatry and Neurostimulation, University Hospitals of Strasbourg, University of Strasbourg, Strasbourg, FRANCE; UMR CNRS 7357, Engineering Science, Computer Science and Imaging Laboratory (ICube), University of Strasbourg, Strasbourg, FRANCE
Schefzik, Roman; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Foucher, Jack R.; Department of Elderly Psychiatry and Neurostimulation, University Hospitals of Strasbourg, University of Strasbourg, Strasbourg, FRANCE; UMR CNRS 7357, Engineering Science, Computer Science and Imaging Laboratory (ICube), University of Strasbourg, Strasbourg, FRANCE
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm GERMANY
Bokde, Arun L.W.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Desrivières, Sylvane; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Garavan, Hugh; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Gowland, Penny; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, UK
Grigis, Antoine; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Heinz, Andreas; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany; German Center for Mental Health (DZPG), Site Tübingen, GERMANY
Martinot, Jean-Luc; Institut National de la Santé et de la Recherche Médicale, INSERM U A10 “Trajectoires développementales & psychiatrie,” University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS; Centre Borelli, Gif-sur-Yvette, FRANCE
Paillère Martinot, Marie-Laure; AP-HP, Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, FRANCE; Institut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales & psychiatrie," University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS; Centre Borelli, Gif-sur-Yvette, FRANCE
Artiges, Eric; Psychiatry Department, EPS Barthélémy Durand, Etampes, FRANCE; Institut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales & psychiatrie," University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS; Centre Borelli, Gif-sur-Yvette, FRANCE
Papadopoulos Orfanos, Dimitri; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Poustka, Luise; Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, GERMANY
Smolka, Michael N.; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, GERMANY
Hohmann, Sarah; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm GERMANY
Vaidya, Nilakshi; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, GERMANY
Walter, Henrik; Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Whelan, Robert; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, Gunter; German Center for Mental Health (DZPG), Site Berlin-Potsdam, GERMANY; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, GERMANY; Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Nees, Frauke; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, GERMANY; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm
Schwarz, Emanuel; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Löffler, Martin; Clinical Psychology, Department of Experimental Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, GERMANY
Flor, Herta; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Introduction: The bidirectional relationship between pain and affective symptoms suggests shared underlying mechanisms. Neurophysiological changes, psychosocial factors, and specifically alterations in instrumental learning likely contribute significantly to their co-occurrence.
Objectives: In this study, we aimed to uncover factors associated with the comorbidity between pain and the severity of depressive symptoms and between pain and the severity of anxiety symptoms.
Methods: We analyzed psychosocial (n = 624) and neuroimaging (n = 689) data from a European sample of young adults with pain and affective symptoms from the general population. Using multitask learning, we constructed cross-sectional models predicting the coexistence of both symptom domains.
Results: Based on blood-oxygen-level-dependent responses during reward feedback, we found a neural pattern associated with the comorbidity between pain and the severity of depressive symptoms, reflecting regionally heterogeneous alterations in reward responsivity. These alterations included stronger negative responses in the caudate nucleus and putamen. In addition, we identified robust psychosocial markers of the comorbidity between pain and the severity of either depressive or anxiety symptoms, among which nonpainful somatic symptoms and persistent rumination showed the most robust association. We further compared the predictive capabilities of psychosocial markers with those of neural processes in instrumental learning and found that neural signatures of reward feedback improved the prediction of a psychosocial signature for the comorbidity between pain and the severity of depressive symptoms.
Conclusion: These findings highlight the presence of common mechanisms underlying the comorbidity of pain and affective symptoms, including alterations in the neural responses to reward.
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Rechteinformation
CC BY 4.0 ; Creative Commons Attribution 4.0 License
Zitierung
Scarlatti, F., Dormegny-Jeanjean, L., Schefzik, R., Foucher, J. R., Banaschewski, T., Bokde, A. L., Brühl, R., Desrivières, S., Garavan, H., Gowland, P., Grigis, A., Heinz, A., Martinot, J.-L., Paillère Martinot, M.-L., Artiges, E., Papadopoulos Orfanos, D., Poustka, L., Smolka, M. N., Hohmann, S., Vaidya, N., Walter, H., Whelan, R., Schumann, G., Nees, F., Schwarz, E., Löffler, M., & Flor, H. (2025). Neural and psychosocial signatures of the comorbidity between pain and affective symptoms. PAIN Reports, 11(1), 1–11. https://doi.org/10.1097/pr9.0000000000001353
