Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth
Autor(in); Institution
Cheng, Annie; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
Lichenstein, Sarah; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
Chaarani, Bader; Department of Psychiatry, University of Vermont, Burlington, VT, USA
Liang, Qinghao; Department of Biomedical Engineering, Yale University, New Haven, CT, USA
Babaeianjelodar, Marzieh; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
Riley, Steven J.; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
Luo, Wenjing; Department of Biomedical Engineering, Yale University, New Haven, CT, USA
Horien, Corey; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA; MD/PhD program, Yale School of Medicine, New Haven, CT, USA
Greene, Abigail S.; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA; MD/PhD program, Yale School of Medicine, New Haven, CT, USA; Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Mannheim, GERMANY
Bokde, Arun L. W.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Desrivières, Sylvane; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Flor, Herta; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Grigis, Antoine; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Gowland, Penny; Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Heinz, Andreas; Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Martinot, Jean-Luc; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales en psychiatrie", Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, FRANCE
Martinot, Marie-Laure Paillère; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales en psychiatrie", Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, FRANCE; AP-HP. Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, FRANCE
Artiges, Eric; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales en psychiatrie", Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, FRANCE; Psychiatry Department, EPS Barthélémy Durand, Etampes, FRANCE
Nees, Frauke; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, GERMANY
Papadopoulos Orfanos, Dimitri; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Poustka, Luise; Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, GERMANY
Hohmann, Sarah; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Holz, Nathalie; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Baeuchl, Christian; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, GERMANY
Smolka, Michael N.; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, GERMANY
Vaidya, Nilakshi; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, GERMANY
Walter, Henrik; Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Whelan, Robert; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, Gunter; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany; Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Constable, R. Todd; Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA
Pearlson, Godfrey; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA
Garavan, Hugh; Department of Psychiatry, University of Vermont, Burlington, VT, USA; Department of Psychology, University of Vermont, Burlington, VT, USA
Yip, Sarah W.; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Child Study Center, Yale School of Medicine, New Haven, CT, USA
Increases in impulsivity and negative affect (e.g., neuroticism) are common during adolescence and are both associated with risk for alcohol-use initiation and other risk behaviors. Whole-brain functional connectivity approaches-when coupled with appropriate cross-validation-enable identification of complex neural networks subserving individual differences in dimensional traits (hereafter referred to as 'neural signatures'). Here, we analyzed functional connectivity data acquired at age 19 from individuals enrolled in a multisite European study of adolescent development (N ~ 1100) using connectome-based predictive modeling. Network anatomies of these dimensional phenotypes were compared with one another and with a previously identified alcohol-use risk network to identify shared and unique neural mechanisms. Models accurately predicted both impulsivity and neuroticism (r's ~ 0.17-0.19, p's < 0.05), and successfully generalized to an external sample. The impulsivity network was predominantly characterized by motor/sensory-related connections. By contrast, the neural signature of neuroticism was relatively more distributed across multiple canonical networks, including motor/sensory, default mode, subcortical, frontoparietal and cerebellar networks. Very few connections were common to both impulsivity and neuroticism networks. Moreover, while ~10-20% of the connections from each trait overlapped with the alcohol-use risk network, these connections were distinct between the two traits. This study for the first time identifies functional connectivity signatures of two common risk factors for alcohol-use in youth-impulsivity and neuroticism. Consistent with current equifinality-based conceptions of development, few connections predicted both impulsivity and neuroticism, indicating that the neural signatures of these two traits are relatively distinct despite both being implicated in alcohol-use risk and a wide array of behaviors.
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CC BY 4.0 ; Creative Commons Attribution 4.0 License
Zitierung
Cheng, A., Lichenstein, S., Chaarani, B., Liang, Q., Babaeianjelodar, M., Riley, S. J., Luo, W., Horien, C., Greene, A. S., Banaschewski, T., Bokde, A. L. W., Desrivières, S., Flor, H., Grigis, A., Gowland, P., Heinz, A., Brühl, R., Martinot, J.-L., Martinot, M.-L. P., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Poustka, L., Hohmann, S., Holz, N., Baeuchl, C., Smolka, M. N., Vaidya, N., Walter, H., Whelan, R., Schumann, G., Constable, R. T., Pearlson, G., Garavan, H., & Yip, S. W. (2026). Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth. Molecular Psychiatry, 31, 953–962. https://doi.org/10.1038/s41380-025-03196-6
