Mapping the coupling between tract reachability and cortical geometry of the human brain
Autor(in); Institution
Li, Deying; Beijing Key Laboratory of Brainnetome and Brain-Computer Interface, Institute of Automation, Chinese Academy of Sciences, Beijing, CHINA
Zalesky, Andrew; Systems Lab, Department of Psychiatry, The University of Melbourne, Victoria, VIC, AUSTRALIA
Wang, Yufan; Beijing Key Laboratory of Brainnetome and Brain-Computer Interface, Institute of Automation, Chinese Academy of Sciences, Beijing, CHINA
Wang, Haiyan; Beijing Key Laboratory of Brainnetome and Brain-Computer Interface, Institute of Automation, Chinese Academy of Sciences, Beijing, CHINA
Ma, Liang; Beijing Key Laboratory of Brainnetome and Brain-Computer Interface, Institute of Automation, Chinese Academy of Sciences, Beijing, CHINA
Cheng, Luqi; School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, CHINA
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, German Center for Mental Health (DZPG), Mannheim, Germany
Barker, Gareth J.; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Bokde, Arun L. W.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Desrivières, Sylvane; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Flor, Herta; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychology, GERMANY
Garavan, Hugh; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Gowland, Penny; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Grigis, Antoine; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Heinz, Andreas; Department of Psychiatry and Psychotherapy CCM, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, GERMANY
Lemaître, Hervé; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France Institut des Maladies Neurodégénératives, UMR 5293, CNRS, CEA, Université de Bordeaux, Bordeaux, FRANCE
Martinot, Jean-Luc; Institut National de la Santé et de la Recherce Médicale, INSERM U1299 “Trajectoires développementales & psychiatrie”, University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay; Centre Borelli CNRS 9010, Gif-sur-Yvette, FRANCE
Martinot, Marie-Laure Paillère; Institut National de la Santé et de la Recherce Médicale, INSERM U1299 “Trajectoires développementales & psychiatrie”, University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay; Centre Borelli CNRS 9010, Gif-sur-Yvette, FRANCE
Artiges, Eric; Institut National de la Santé et de la Recherce Médicale, INSERM U1299 “Trajectoires développementales & psychiatrie”, University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay; Centre Borelli CNRS 9010, Gif-sur-Yvette, FRANCE
Nees, Frauke; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, German Center for Mental Health (DZPG), Mannheim, GERMANY
Orfanos, Dimitri Papadopoulos; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Poustka, Luise; Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, GERMANY
Smolka, Michael N.; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, GERMANY
The study of cortical geometry and connectivity is prevalent in human brain research. However, these two aspects of brain structure are usually examined separately, leaving the essential connections between the brain’s folding patterns and white matter connectivity unexplored. In this study, we aim to elucidate the fundamental links between cortical geometry and white matter tract connectivity. We develop the concept of tract-geometry coupling (TGC) by optimizing the alignment between tract connectivity to the cortex and multiscale cortical geometry. We confirm in two independent datasets that cortical geometry reliably characterizes tract reachability, and that TGC demonstrates high test-retest reliability and individual-specificity. Interestingly, low-frequency TGC is more heritable and behaviorally informative. Finally, we find that TGC can reproduce task-evoked cortical activation patterns and exhibits non-uniform maturation during youth. Collectively, our study provides an approach to mapping cortical geometry-connectivity coupling, highlighting how these two aspects jointly shape the connected brain.
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Open Access Gold
Rechteinformation
CC BY 4.0 ; Creative Commons Attribution 4.0 License
Zitierung
Li, D., Zalesky, A., Wang, Y., Wang, H., Ma, L., Cheng, L., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Brühl, R., Desrivières, S., Flor, H., Garavan, H., Gowland, P., Grigis, A., Heinz, A., Lemaître, H., Martinot, J.-L., Martinot, M.-L. P., Artiges, E., Nees, F., Orfanos, D. P., Poustka, L., & Smolka, M. N. (2025). Mapping the coupling between tract reachability and cortical geometry of the human brain. Nature Communications, 16(1), 1–18. https://doi.org/10.1038/s41467-025-62812-9
