Abstract Summary: A novel steady-state CEST sequence design, based on the underlying physical model of longitudinal magnetisation development during CEST saturation and data acquisition is presented and validated in-silico, in vitro and in vivo. This design ensures consistent data acquisition in the pure CEST steady-state, leading to high MTRasym scores and image quality, both in vitro and in vivo, when compared to contemporary sequential and steady-state CEST sequences.
Purpose: The aim of this study was to enhance CEST sequences by utilizing the pure CEST steady-state in order to deliver higher CEST effects and better sensitivity.
Methods: A novel CEST saturation/readout scheme was designed, tested in numerical simulations and subsequently validated in vitro and in vivo.
Results: The novel Multi-2D Spiral pure steady-state CEST sequence showed to deliver advantageous sensitivity and efficacy.
Conclusion: Constraining image acquisition to the pure CEST steady-state showed promising results in first in vitro and in vivo experiments.
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Rechteinformation
CC BY 4.0 ; Creative Commons Attribution 4.0 License
Förderinformationen (1)
Förderername: Deutsche Forschungsgemeinschaft (DFG)
Zitierung
Hammacher, J., Kolbitsch, C., & Schünke, P. (2025). Pure steady-state CEST. Magnetic Resonance Imaging, 124, 110506-1–110506-7. https://doi.org/10.1016/j.mri.2025.110506
