| Zugriffsnummer | 53917 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | The influence of atomic number on the radiosensitization efficiency of metallic nanorods: A Monte Carlo simulation study |
| Autor(in); Institution |
Taheri, A.; Applied Physics and Radiation Technologies Group, CCDCU, School of Engineering and Technology, Sunway University, Bandar Sunway, Selangor, MALAYSIA
Khandaker, M.U.; Applied Physics and Radiation Technologies Group, CCDCU, School of Engineering and Technology, Sunway University, Bandar Sunway, Selangor, MALAYSIA; Faculty of Graduate Studies, Daffodil International University, Dhaka, Daffodil Smart City, BANGLADESH; Department of Physics, College of Science, Korea University, Seoul, REPUBLIC OF KOREA
Moradi, F.; Radiation Dosimetry Research Group, Faculty of Engineering, Multimedia University, Cyberjaya, MALAYSIA
Bradley, D.A.; Applied Physics and Radiation Technologies Group, CCDCU, School of Engineering and Technology, Sunway University, Bandar Sunway, Selangor, MALAYSIA; School of Mathematics and Physics, University of Surrey, Guildford, UK
|
| Quelle/Jahr | Radiation Physics and Chemistry: 230 (2025), 1 - 8 |
| Artikelnummer | 112589 |
| ISSN | 0969-806X (print) ; 1879-0895 (online) |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Freie Schlagworte | metallic nanorod ; nanoparticle radiosensitization ; dose enhancement ratio ; TOPAS |
| Zusammenfassung | The biological response to light ion irradiation is influenced by complex DNA damage, which is closely associated with the particle track structure. This study aims to explore the correlation between nanoscale ionization distribution and the likelihood of inducing cell death in both aerobic and hypoxic cells. Monte Carlo track-structure simulations were conducted for protons, helium, carbon, and neon ions of various energies, interacting with a gaseous spherical target volume with a water equivalent diameter of 1 nm. The simulations employed the MC-Startrack code, which accurately reproduces the experimental response of the Startrack counter, the nanodosimeter developed at the Legnaro National Laboratories of INFN. The primary particles were directed through the centre of the sphere, with impact parameters set to zero. The link to radiobiology was explored. The results reveal significant correlations between the inactivation cross sections reported by Furusawa, for both aerobic and hypoxic cells, and linear combinations of cumulative probabilities of measuring more than 1, 2 or 3 ionizations. The proportionality factor, unique to each cell line, represents the saturation value of biological cross sections. |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Taheri, A., Khandaker, M., Rabus, H., Moradi, F., & Bradley, D. (2025). The influence of atomic number on the radiosensitization efficiency of metallic nanorods: A Monte Carlo simulation study. Radiation Physics and Chemistry, 230, 1–8. https://doi.org/10.1016/j.radphyschem.2025.112589