| Zugriffsnummer | 53884 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Striato-pallidal oscillatory connectivity correlates with symptom severity in dystonia patients |
| Autor(in); Institution |
Lofredi, R.; Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, GERMANY; Berlin Institute of Health (BIH), Berlin, GERMANY
Feldmann, L. K.; Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Krause, P.; Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Scheller, U.; Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, GERMANY; Department of Neurology, Universität Göttingen, Göttingen, GERMANY
Neumann, W.-J.; Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, GERMANY; Bernstein Center for Computational Neuroscience, Humboldt-Universität zu Berlin, Berlin, GERMANY
Krauss, J. K.; Department of Neurosurgery, Medizinische Hochschule Hannover, Hannover, GERMANY
Saryyeva, A.; Department of Neurosurgery, Medizinische Hochschule Hannover, Hannover, GERMANY
Schneider, G.-H.; Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Faust, K.; Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Kühn, A. A.; Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, GERMANY; Bernstein Center for Computational Neuroscience, Humboldt-Universität zu Berlin, Berlin, GERMANY; NeuroCure, Exzellenzcluster, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
|
| Quelle/Jahr | Nature Communications: 15 (2024), 1, 1 - 8 |
| Artikelnummer | 8475 |
| Availability | [online only] |
| ISSN | 2041-1723 (online) |
| DOI | |
| URL | |
| Verlag | London: Nature Publishing Group |
| Zusammenfassung | Dystonia is a hyperkinetic movement disorder that has been associated with an imbalance towards the direct pathway between striatum and internal pallidum, but the neuronal underpinnings of this abnormal basal ganglia pathway activity remain unknown. Here, we report invasive recordings from ten dystonia patients via deep brain stimulation electrodes that allow for parallel recordings of several basal ganglia nuclei, namely the striatum, external and internal pallidum, that all displayed activity in the low frequency band (3–12 Hz). In addition to a correlation with low-frequency activity in the internal pallidum (R = 0.88, P = 0.001), we demonstrate that dystonic symptoms correlate specifically with low-frequency coupling between striatum and internal pallidum (R = 0.75, P = 0.009). This points towards a pathophysiological role of the direct striato-pallidal pathway in dystonia that is conveyed via coupling in the enhanced low-frequency band. Our study provides a mechanistic insight into the pathophysiology of dystonia by revealing a link between symptom severity and frequency-specific coupling of distinct basal ganglia pathways. |
| Kostenfreier Zugang | Open Access Hybrid |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Lofredi, R., Feldmann, L. K., Krause, P., Scheller, U., Neumann, W.-J., Krauss, J. K., Saryyeva, A., Schneider, G.-H., Faust, K., Sander-Thömmes, T., & Kühn, A. A. (2024). Striato-pallidal oscillatory connectivity correlates with symptom severity in dystonia patients. Nature Communications, 15(1), 1–8. https://doi.org/10.1038/s41467-024-52814-4