Lumos: Software for multi-level multi-reader comparison of cardiovascular magnetic resonance late Gadolinium enhancement scar quantification
Autor(in); Institution
Reisdorf, Philine; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité - Universitätsmedizin Berlin and the Max-Delbrück-Center for Molecular Medicine, Berlin, GERMANY; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, ECRC Experimental and Clinical Research Center, Berlin, GERMANY; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, GERMANY
Gavrysh, Jonathan; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité - Universitätsmedizin Berlin and the Max-Delbrück-Center for Molecular Medicine, Berlin, GERMANY; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, ECRC Experimental and Clinical Research Center, Berlin, GERMANY; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, GERMANY
Ammann, Clemens; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité - Universitätsmedizin Berlin and the Max-Delbrück-Center for Molecular Medicine, Berlin, GERMANY; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, ECRC Experimental and Clinical Research Center, Berlin, GERMANY; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, GERMANY
Fenski, Maximilian; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité - Universitätsmedizin Berlin and the Max-Delbrück-Center for Molecular Medicine, Berlin, GERMANY; Clinical Research Center, Berlin, GERMANY; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, GERMANY
Lange, Steffen; Department of Computer Sciences, Hochschule Darmstadt - University of Applied Sciences, Darmstadt, GERMANY
Hennemuth, Anja; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, GERMANY; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY; Fraunhofer MEVIS, Bremen, GERMANY
Schulz-Menger, Jeanette; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité - Universitätsmedizin Berlin and the Max-Delbrück-Center for Molecular Medicine, Berlin, GERMANY; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, ECRC Experimental and Clinical Research Center, Berlin, GERMANY; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, GERMANY
Hadler, Thomas; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité - Universitätsmedizin Berlin and the Max-Delbrück-Center for Molecular Medicine, Berlin, GERMANY; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, ECRC Experimental and Clinical Research Center, Berlin, GERMANY; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, GERMANY
Quelle/Jahr
Journal of Imaging Informatics in Medicine: 38
(2025), 4167
- 4183
Cardiovascular magnetic resonance ; Comparison software ; Late gadolinium enhancement ; Quality assurance ; Scar quantification
Zusammenfassung
Cardiovascular magnetic resonance imaging (CMR) offers state-of-the-art myocardial tissue differentiation. The CMR technique late gadolinium enhancement (LGE) currently provides the noninvasive gold standard for the detection of myocardial fibrosis. Typically, thresholding methods are used for fibrotic scar tissue quantification. A major challenge for standardized CMR assessment is large variations in the estimated scar for different methods. The aim was to improve quality assurance for LGE scar quantification, a multi-reader comparison tool “Lumos” was developed to support quality control for scar quantification methods. The thresholding methods and an exact rasterization approach were implemented, as well as a graphical user interface (GUI) with statistical and case-specific tabs. Twenty LGE cases were considered with half of them including artifacts and clinical results for eight scar quantification methods computed. Lumos was successfully implemented as a multi-level multi-reader comparison software, and differences between methods can be seen in the statistical results. Histograms visualize confounding effects of different methods. Connecting the statistical level with the case level allows for backtracking statistical differences to sources of differences in the threshold calculation. Being able to visualize the underlying groundwork for the different methods in the myocardial histogram gives the opportunity to identify causes for different thresholds. Lumos showed the differences in the clinical results between cases with artifacts and cases without artifacts. A video demonstration of Lumos is offered as supplementary material 1. Lumos allows for a multi-reader comparison for LGE scar quantification that offers insights into the origin of reader differences.
Kostenfreier Zugang
Open Access Hybrid
Rechteinformation
CC BY 4.0 ; Creative Commons Attribution 4.0 License
Förderinformationen (1)
Förderername: Deutsche Forschungsgemeinschaft (DFG)
Förderer ID: 0000 0001 2096 9829
Förderer ID Typ: ISNI
Förderprogramm: GRK 2260, BIOQIC
Förderinformationen (2)
Förderername: Deutsche Herzstiftung e.V.
Förderer ID: 0000 0004 0563 0626
Förderer ID Typ: ISNI
Förderungsnummer: S/09/23
Reisdorf, P., Gavrysh, J., Ammann, C., Fenski, M., Kolbitsch, C., Lange, S., Hennemuth, A., Schulz-Menger, J., & Hadler, T. (2025). Lumos: Software for multi-level multi-reader comparison of cardiovascular magnetic resonance late Gadolinium enhancement scar quantification. Journal of Imaging Informatics in Medicine, 38, 4167–4183. https://doi.org/10.1007/s10278-025-01437-2
