| Zugriffsnummer | 53533 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Identification and external validation of a problem cannabis risk network |
| Autor(in); Institution |
Kiluk, Brian D.; Department of Psychiatry, Yale School of Medicine, New Haven, USA
Potenza, Marc N.; Department of Psychiatry, Yale School of Medicine, New Haven, CT; Child Study Center, Yale School of Medicine, New Haven, CT; Connecticut Mental Health Center, New Haven, CT; Connecticut Council on Problem Gambling, Wethersfield, CT; Wu Tsai Institute, Yale University, New Haven, CT; Department of Neuroscience, Yale University, New Haven, CT, USA
Garavan, Hugh; Department of Psychiatry, University of Vermont; Department of Psychology, University of Vermont, USA
Chaarani, Bader; Department of Psychiatry, University of Vermont, USA
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany, German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, GERMANY
Bokde, Arun L.W.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Desrivières, Sylvane; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK
Flor, Herta; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, 68131 Mannheim, GERMANY
Grigis, Antoine; NeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, FRANCE
Gowland, Penny; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Heinz, Andreas; Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Martinot, Jean-Luc; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales en psychiatrie"; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli; Gif-sur-Yvette, France; Psychiatry Department, EPS Barthélémy Durand, Etampes, FRANCE
Paillère Martinot, Marie-Laure; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales en psychiatrie"; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli; Gif-sur-Yvette, France; AP-HP. Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, FRANCE
Artiges, Eric; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales en psychiatrie"; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli; Gif-sur-Yvette, FRANCE; Psychiatry Department, EPS Barthélémy Durand, Etampes, FRANCE
Nees, Frauke; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, GERMANY
Orfanos, Dimitri Papadopoulos; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Poustka, Luise; Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, GERMANY
Hohmann, Sarah; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, GERMANY
Holz, Nathalie; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Baeuchl, Christian; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Smolka, Michael N.; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, GERMANY
Vaidya, Nilakshi; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, GERMANY
Walter, Henrik; member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Whelan, Robert; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Germany; Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Schumann, Gunter; Department of Psychiatry, Yale School of Medicine, New Haven, CT; Wu Tsai Institute, Yale University, New Haven, CT; Department of Neuroscience, Yale University, New Haven, CT, USA
Pearlson, Godfrey; Department of Psychiatry, Yale School of Medicine, New Haven, CT; Wu Tsai Institute, Yale University, New Haven, CT; Department of Neuroscience, Yale University, New Haven, CT , USA
Yip, Sarah W.; Department of Psychiatry, Yale School of Medicine, New Haven, CT; Child Study Center, Yale School of Medicine, New Haven, CT, USA
|
| Quelle/Jahr | Biological Psychiatry: 98 (2025), 8, 586 - 596 |
| ISSN | 0006-3223 (print) ; 1873-2402 (online) |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Freie Schlagworte | emerging adulthood ; external replication ; functional connectivity ; marijuana ; neuromarker ; predictive modelling |
| Zusammenfassung | Background: Cannabis use is common, particularly during emerging adulthood when brain development is ongoing, and its use is associated with harmful outcomes for a subset of people. An improved understanding of the neural mechanisms underlying risk for problem-level use is critical to facilitate the development of more effective prevention and treatment approaches. Methods: The current study applied a whole-brain, data-driven, machine-learning approach to identify neural features predictive of problem-level cannabis use in a non-clinical sample of college students (n=191, 58% female) based on reward task functional connectivity data. We further examined whether the network identified would generalize to predict cannabis use in an independent sample of European adolescents/emerging adults (n=1320, 53% female), whether it would predict clinical characteristics among adults seeking treatment for cannabis use disorder (n=33, 9% female), and whether it was specific for predicting cannabis versus alcohol use outcomes across datasets. Results: Results demonstrated (i) identification of a problem cannabis risk network, which (ii) generalized to predict cannabis use in an independent sample of adolescents, and (iii) linked to increased addiction severity and poorer treatment outcome in a third sample of treatment-seeking adults; further, (iv) the identified network was specific for predicting cannabis versus alcohol use outcomes across all three datasets. Conclusions: Findings provide insight into neural mechanisms of risk for problem-level cannabis use among adolescents/emerging adults. Future work is needed to assess whether targeting this network can improve prevention and treatment outcomes. |
| Förderinformationen (1) | Förderername: National Institute on Drug Abuse |
Zitierung
Lichenstein, S. D., Kiluk, B. D., Potenza, M. N., Garavan, H., Chaarani, B., Banaschewski, T., Bokde, A. L., Desrivières, S., Flor, H., Grigis, A., Gowland, P., Heinz, A., Brühl, R., Martinot, J.-L., Paillère Martinot, M.-L., Artiges, E., Nees, F., Orfanos, D. P., Poustka, L., Hohmann, S., Holz, N., Baeuchl, C., Smolka, M. N., Vaidya, N., Walter, H., Whelan, R., Schumann, G., Pearlson, G., & Yip, S. W. (2025). Identification and external validation of a problem cannabis risk network. Biological Psychiatry, 98(8), 586–596. https://doi.org/10.1016/j.biopsych.2025.01.022