| Zugriffsnummer | 53310 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Multimodal investigations of structural and functional brain alterations in anorexia and bulimia nervosa and their relationships to psychopathology |
| Autor(in); Institution |
Yu, Xinyang; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Robinson, Lauren; Department of Psychological Medicine, Centre for Research in Eating and Weight Disorders, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; South London and Maudsley NHS Foundation Trust, London, UK; Oxford Institute of Clinical Psychology Training and Research, Oxford University, Oxford, UK
Bobou, Marina; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Division of Psychiatry and Department of Clinical, Educational & Health Psychology, University College London, London, UK
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Barker, Gareth J; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Bokde, Arun L W; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, IRELAND
Flor, Herta; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Grigis, Antoine; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Garavan, Hugh; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Gowland, Penny; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, UK
Heinz, Andreas; Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Brühl, Rüdiger; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, Jean-Luc; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 "Developmental trajectories & psychiatry"; Université Paris-Saclay, Université Paris Cité, Ecole Normale supérieure Paris-Saclay, CNRS; Centre Borelli UMR9010; Gif-sur-Yvette, FRANCE
Paillère Martinot, Marie-Laure; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 "Developmental trajectories & psychiatry"; Université Paris-Saclay, Université Paris Cité, Ecole Normale supérieure Paris-Saclay, CNRS; Centre Borelli UMR9010; Gif-sur-Yvette, France; AP-HP. Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, FRANCE
Artiges, Eric; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 "Developmental trajectories & psychiatry"; Université Paris-Saclay, Université Paris Cité, Ecole Normale supérieure Paris-Saclay, CNRS; Centre Borelli UMR9010; Gif-sur-Yvette, France; Psychiatry Department, EPS Barthélémy Durand, Etampes, FRANCE
Nees, Frauke; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, GERMANY
Papadopoulos Orfanos, Dimitri; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Lemaître, Hervé; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France; Institut des Maladies Neurodégénératives, UMR 5293, CNRS, CEA, Université de Bordeaux, Bordeaux, FRANCE
Poustka, Luise; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Hohmann, Sarah; Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Medical Center Hamburg-Eppendorf, Hamburg, GERMANY
Holz, Nathalie; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bäuchl, Christian; Faculty of Psychology, Technische Universität Dresden, Dresden, Germany; Department of Psychiatry, Technische Universität Dresden, Dresden, GERMANY
Smolka, Michael N.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Stringaris, Argyris; Division of Psychiatry and Department of Clinical, Educational & Health Psychology, University College London, London, UK
Walter, Henrik; Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Whelan, Robert; School of Psychology and Global Brain Health Institute, Trinity College, Dublin, IRELAND
Sinclair, Julia; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
Schumann, Gunter; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin, Berlin, Germany; Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Schmidt, Ulrike; Department of Psychological Medicine, Centre for Research in Eating and Weight Disorders, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; South London and Maudsley NHS Foundation Trust, London, UK
Desrivières, Sylvane; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
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| Quelle/Jahr | Biological Psychiatry: 98 (2025), 3, 237 - 248 |
| ISSN | 0006-3223 (print) ; 1873-2402 (online) |
| DOI | |
| Verlag | Amsterdam [u.a.]: Elsevier |
| Freie Schlagworte | Eating disorder ; anorexia nervosa ; bulimia nervosa ; cognitive restraint ; magnetic resonance imaging ; reward processing |
| Zusammenfassung | Background: Neurobiological understanding of eating disorders (EDs) is limited. This study presents the first comparative multi-modal magnetic resonance imaging (MRI) assessments of anorexia nervosa (AN) and bulimia nervosa (BN), uncovering neurobiological differences associated with these disorders. Methods: This female case-control study included 57 healthy controls (HC) and 130 participants with EDs (BN and AN subtypes). Structural and functional MRI assessed gray matter volume (GMV), cortical thickness (CT), and task-based activities related to reward processing, social-emotional functioning, and response inhibition. Whole-brain group differences were correlated to ED psychopathology. Results: Significant structural differences were observed in the ED group compared to HCs, including reduced GMV in the left lateral orbitofrontal cortex and lower CT in the left rostral middle frontal gyrus and precuneus, after adjusting for BMI. Specific structural alterations were only evident in AN subgroups. GMV reductions in the orbitofrontal cortex were linked to impulsivity, while lower CT in the frontal gyrus correlated with cognitive restraint in eating, suggesting these regions may play key roles in ED psychopathology. Functional MRI also revealed notable differences. During reward anticipation, participants with EDs exhibited deactivations in the cerebellum and right superior frontal gyrus, alongside reduced activation in the left lingual gyrus. These functional changes were associated with heightened neuroticism. Mediation analyses suggested that starvation-related GMV reductions in EDs disrupt reward-related brain function, increase neuroticism, and reinforce cognitive restraint, likely contributing to the persistence of ED symptoms. Conclusions: These findings illuminate key neurobehavioral mechanisms underlying EDs, pointing to potential brain-based targets for developing specialized treatment. |
| Kostenfreier Zugang | Open Access Hybrid |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
Zitierung
Yu, X., Robinson, L., Bobou, M., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Brühl, R., Martinot, J.-L., Paillère Martinot, M.-L., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Lemaître, H., Poustka, L., Hohmann, S., Holz, N., Bäuchl, C., Smolka, M. N., Stringaris, A., Walter, H., Whelan, R., Sinclair, J., Schumann, G., Schmidt, U., & Desrivières, S. (2025). Multimodal investigations of structural and functional brain alterations in anorexia and bulimia nervosa and their relationships to psychopathology. Biological Psychiatry, 98(3), 237–248. https://doi.org/10.1016/j.biopsych.2024.11.008