Plasma p-tau181 and GFAP reflect 7T MR-derived changes in Alzheimer's disease: A longitudinal study of structural and functional MRI and MRS
Autor(in); Institution
Göschel, Laura; Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY
Dell’Orco, Andrea; Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Riemann, Layla; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin; Institute for Applied Medical Informatics, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, GERMANY
Lehmann, Sylvain; LBPC-PPC, Université de Montpellier, INM INSERM, IRMB CHU de Montpellier, Montpellier, France
Cano, Stefan; Modus Outcomes Ltd, Cheltenham, UK
Melin, Jeanette; Division Safety and Transport, Division Measurement Science and Technology, RISE, Research Institutes of Sweden, Gothenburg, SWEDEN
Pendrill, Lesie; Division Safety and Transport, Division Measurement Science and Technology, RISE, Research Institutes of Sweden, Gothenburg, SWEDEN
Hoede, Patty L.; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the NETHERLANDS
Teonissen, Charlotte E.; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the NETHERLANDS
Schwarz, Claudia; Institute of Biometry and Clinical Epidemiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY; Department of Neurology, University Medicine Greifswald, Greifswald, GERMANY
Grittner, Ulrike; Institute of Biometry and Clinical Epidemiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY
Körtvélyessy, Péter; Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY
Flöel, Agnes; Department of Neurology, University Medicine Greifswald, Greifswald, GERMANY; German Center for Neurodegenerative Diseases (DZNE), Standort Rostock/Greifswald, Greifswald, GERMANY
BACKGROUND
Associations between longitudinal changes of plasma biomarkers and cerebral magnetic resonance (MR)-derived measurements in Alzheimer's disease (AD) remain unclear.
METHODS
In a study population (n = 127) of healthy older adults and patients within the AD continuum, we examined associations between longitudinal plasma amyloid beta 42/40 ratio, tau phosphorylated at threonine 181 (p-tau181), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and 7T structural and functional MR imaging and spectroscopy using linear mixed models.
RESULTS
Increases in both p-tau181 and GFAP showed the strongest associations to 7T MR-derived measurements, particularly with decreasing parietal cortical thickness, decreasing connectivity of the salience network, and increasing neuroinflammation as determined by MR spectroscopy (MRS) myo-inositol.
DISCUSSION
Both plasma p-tau181 and GFAP appear to reflect disease progression, as indicated by 7T MR-derived brain changes which are not limited to areas known to be affected by tau pathology and neuroinflammation measured by MRS myo-inositol, respectively.
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Open Access Hybrid
Rechteinformation
CC BY 4.0 ; Creative Commons Attribution 4.0 License
Zitierung
Göschel, L., Dell’Orco, A., Fillmer, A., Aydin, S., Ittermann, B., Riemann, L., Lehmann, S., Cano, S., Melin, J., Pendrill, L., Hoede, P. L., Teonissen, C. E., Schwarz, C., Grittner, U., Körtvélyessy, P., & Flöel, A. (2024). Plasma p-tau181 and GFAP reflect 7T MR-derived changes in Alzheimer's disease: A longitudinal study of structural and functional MRI and MRS. Alzheimer's & Dementia, 1–16. https://doi.org/10.1002/alz.14318
