| Zugriffsnummer | 53240 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Hypertrophic obstructive cardiomyopathy-left ventricular outflow tract shapes and their hemodynamic influences applying CMR |
| Autor(in); Institution |
Mayr, T; ECRC Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY
Riazy, L; ECRC Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY; Partner Site Berlin, DZHK (German Centre for Cardiovascular Research), Berlin, GERMANY
Trauzeddel, R F; ECRC Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität and Humboldt Universität zu Berlin, Campus Benjamin Franklin, Berlin, GERMANY
Bassenge, Jean Pierre; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin; ECRC Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY
Wiesemann, S; ECRC Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY; Partner Site Berlin, DZHK (German Centre for Cardiovascular Research), Berlin, GERMANY
Blaszczyk, E; Humboldt-Universität zu Berlin, Berlin, GERMANY; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY; Partner Site Berlin, DZHK (German Centre for Cardiovascular Research), Berlin, GERMANY
Prothmann, M; HELIOS Hospital Berlin-Buch, Berlin, GERMANY
Hadler, T; ECRC Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY
Schulz-Menger, Jeanette; ECRC Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, GERMANY; Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY; HELIOS Hospital Berlin-Buch, Berlin, GERMANY
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| Quelle/Jahr | The International Journal of Cardiovascular Imaging:(2024), 1 - 11 |
| Availability | [online only] |
| ISSN | 1875-8312 (online) |
| DOI | |
| Verlag | Dordrecht [u.a.]: Springer |
| Freie Schlagworte | Cardiovascular magnetic resonance ; Hemodynamics ; Hypertrophic cardiomyopathy ; Hypertrophic obstructive cardiomyopathy ; Left ventricular outflow obstruction ; Shape analysis |
| Zusammenfassung | Hypertrophic cardiomyopathy (HCM) is one of the most common genetic cardiac disorders and is characterized by different phenotypes of left ventricular hypertrophy with and without obstruction. The effects of left ventricular outflow tract (LVOT) obstruction based on different anatomies may be hemodynamically relevant and influence therapeutic decision making. Cardiovascular magnetic resonance (CMR) provides anatomical information. We aimed to identify different shapes of LVOT-obstruction using Cardiovascular Magnetic Resonance (CMR). The study consisted of two parts: An in-vivo experiment for shape analysis and in-vitro part for the assessment of its hemodynamic consequences. In-vivo a 3D depiction of the LVOT was created using a 3D multi-slice reconstruction from 2D-slices (full coverage cine stack with 7 slices and a thickness of 5-6 mm with no gap) in 125 consecutive HOCM patients (age = 64.17 +/- 12.655; female n = 42). In-vitro an analysis of the LVOT regarding shape and flow behavior was conducted. For this purpose, 2D and 4D measurements were performed on 3D printed phantoms which were based on the anatomical characteristics of the in-vivo study, retrospectively. The in-vivo study identified three main shapes named K- (28.8%), X- (51.2%) and V-shape (10.4%) and a mixed one (9.6%). By analyzing the in-vitro flow measurements every shape showed an individual flow profile in relation to the maximum velocity in cm/s. Here, the V-shape showed the highest value of velocity (max. 138.87 cm/s). The X-shape was characterized by a similar profile but with lower velocity values (max. 125.39 cm/s), whereas the K-shape had an increase of the velocity without decrease (max. 137.11 cm/s). For the first time three different shapes of LVOT-obstruction could be identified. These variants seem to affect the hemodynamics in HOCM. |
| Kostenfreier Zugang | Open Access Hybrid |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
Zitierung
Mayr, T., Riazy, L., Trauzeddel, R. F., Bassenge, J. P., Wiesemann, S., Blaszczyk, E., Prothmann, M., Hadler, T., Schmitter, S., & Schulz-Menger, J. (2024). Hypertrophic obstructive cardiomyopathy-left ventricular outflow tract shapes and their hemodynamic influences applying CMR. The International Journal of Cardiovascular Imaging, 1–11. https://doi.org/10.1007/s10554-024-03242-4