| Zugriffsnummer | 53135 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Regional patterns of human cortex development correlate with underlying neurobiology |
| Autor(in); Institution |
Lotter, Leon D; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, GERMANY; Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University, Düsseldorf, GERMANY; Max Planck School of Cognition, Leipzig, GERMANY
Saberi, Amin; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, GERMANY; Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University, Düsseldorf, GERMANY; Otto Hahn Research Group for Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GERMANY
Hansen, Justine Y.; McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, QC, CANADA
Misic, Bratislav; McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, QC, CANADA
Paquola, Casey; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, GERMANY
Barker, Gareth J; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Bokde, Arun L W; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Desrivières, Sylvane; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK
Flor, Herta; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Grigis, Antoine; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Garavan, Hugh; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Gowland, Penny; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham; University Park, Nottingham, UK
Heinz, Andreas; Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Brühl, Rüdiger; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, Jean-Luc; Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, Université paris Cité, INSERM U1299 Trajectoires Développementales & Psychiatrie, Gif-sur-Yvette, FRANCE
Paillère, Marie-Laure; Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, Université paris Cité, INSERM U1299 Trajectoires Développementales & Psychiatrie, Gif-sur-Yvette, FRANCE
Artiges, Eric; Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, Université paris Cité, INSERM U1299 Trajectoires Développementales & Psychiatrie, Gif-sur-Yvette, FRANCE
Papdopoulos Orfanos, Dimitri; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Paus, Tomas; Departments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montréal, QC, CANADA
Poustka, Luise; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Hohmann, Sarah; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Fröhner, Juliane H.; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, GERMANY
Smolka, Michael N.; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, GERMANY
Vaidya, Nilakshi; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Berlin, GERMANY
Walter, Henrik; Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Whelan, Robert; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, Gunter; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Berlin, GERMANY
Nees, Frauke; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Eickhoff, Simon B.; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, GERMANY
Dukart, Juergen; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, GERMANY
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| Quelle/Jahr | Nature Communications: 15 (2024), 1 - 21 |
| Artikelnummer | 7987 |
| Availability | [online only] |
| ISSN | 2041-1723 (online) |
| DOI | |
| Verlag | London: Springer Nature |
| Zusammenfassung | Human brain morphology undergoes complex changes over the lifespan. Despite recent progress in tracking brain development via normative models, current knowledge of underlying biological mechanisms is highly limited. We demonstrate that human cortical thickness development and aging trajectories unfold along patterns of molecular and cellular brain organization, traceable from population-level to individual developmental trajectories. During childhood and adolescence, cortex-wide spatial distributions of dopaminergic receptors, inhibitory neurons, glial cell populations, and brain-metabolic features explain up to 50% of the variance associated with a lifespan model of regional cortical thickness trajectories. In contrast, modeled cortical thickness change patterns during adulthood are best explained by cholinergic and glutamatergic neurotransmitter receptor and transporter distributions. These relationships are supported by developmental gene expression trajectories and translate to individual longitudinal data from over 8000 adolescents, explaining up to 59% of developmental change at cohort- and 18% at single-subject level. Integrating neurobiological brain atlases with normative modeling and population neuroimaging provides a biologically meaningful path to understand brain development and aging in living humans. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Förderinformationen (1) | Förderername: Open Access funding enabled and organized by Projekt DEAL. |
Zitierung
Lotter, L. D., Saberi, A., Hansen, J. Y., Misic, B., Paquola, C., Barker, G. J., Bokde, A. L. W., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Brühl, R., Martinot, J.-L., Paillère, M.-L., Artiges, E., Papdopoulos Orfanos, D., Paus, T., Poustka, L., Hohmann, S., Fröhner, J. H., Smolka, M. N., Vaidya, N., Walter, H., Whelan, R., Schumann, G., Nees, F., Banaschewski, T., Eickhoff, S. B., & Dukart, J. (2024). Regional patterns of human cortex development correlate with underlying neurobiology. Nature Communications, 15, 1–21. https://doi.org/10.1038/s41467-024-52366-7