Cortical networks of parkinsonian gait: a metabolic and functional connectivity study
Autor(in); Institution
Pellegrin, Franziska; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin Center for Advanced Neuroimaging (BCAN), Berlin, GERMANY; Bernstein Center for Computational Neuroscience, Berlin, GERMANY
Pozzi, Nicoló G.; Department of Neurology, University Hospital of Würzburg and The Julius Maximilian University of Würzburg, Würzburg, GERMANY
Palmisano, Chiara; Department of Neurology, University Hospital of Würzburg and The Julius Maximilian University of Würzburg, Würzburg, GERMANY; Parkinson Institute of Milan, ASST G. Pini-CTO, Milano, ITALY
Marotta, Giorgio; Department of Nuclear Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, ITALY
Buck, Andreas; Department of Nuclear Medicine, University Hospital of Würzburg, Würzburg, GERMANY
Haufe, Stefan; 8.4, Mathematische Modellierung und Datenanalyse, PTB-Berlin; Computer Science Department, Technische Universität Berlin, Berlin, GERMANY; Berlin Center for Advanced Neuroimaging (BCAN), Charité -Universitätsmedizin Berlin, Berlin, GERMANY
Isaias, Ioannis U.; Department of Neurology, University Hospital of Würzburg and The Julius Maximilian University of Würzburg, Würzburg, GERMANY; Parkinson Institute of Milan, ASST G. Pini-CTO, Milano, ITALY
Quelle/Jahr
Annals of Clinical and Translational Neurology:(2024), 1
- 12
Objective: Locomotion is an automated voluntary movement sustained by coordinated neural synchronization across a distributed brain network. The cerebral cortex is central for adapting the locomotion pattern to the environment and alterations of cortical network dynamics can lead to gait impairments. Gait problems are a common symptom with a still unclear pathophysiology and represent an unmet therapeutical need in Parkinson's disease. Little is known about the cortical network dynamics of locomotor control in these patients.
Methods: We studied the cortical basis of parkinsonian gait by combining metabolic brain imaging with high-density EEG recordings and kinematic measurements performed at rest and during unperturbed overground walking.
Results: We found significant changes in functional connectivity between frontal, sensorimotor, and visuomotor cortical areas during walking as compared to resting. Specifically, hypokinetic gait was associated with poor information flow from the supplementary motor area (SMA) to precuneus and from calcarine to lingual gyrus, as well as high information flow from calcarine to cuneus.
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Open Access Gold
Rechteinformation
CC BY 4.0 ; Creative Commons Attribution 4.0 License
Themenbereich der Metrologie
Metrologie in der Medizin
Zitierung
Pellegrin, F., Pozzi, N. G., Palmisano, C., Marotta, G., Buck, A., Haufe, S., & Isaias, I. U. (2024). Cortical networks of parkinsonian gait: a metabolic and functional connectivity study. Annals of Clinical and Translational Neurology, 1–12. https://doi.org/10.1002/acn3.52173
