| Zugriffsnummer | 52886 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood |
| Autor(in); Institution |
Gros, Guillaume; Control-Interoception-Attention Team, Hôpital Pitié-Salpêtrière Paris, Brain Institute, Inserm/CNRS/Sorbonne University, Paris, FRANCE
Marcos, Ruben Miranda; Department of Adult Psychiatry, Centre du Neurodéveloppement Adulte, AP-HP.Sorbonne Université, Pitié-Salpêtrière Hospital, Paris, FRANCE
Saitovitch, Ana; Institut Des Maladies Neurodégénératives, UMR 5293, CNRS, CEA, Université de Bordeaux, Bordeaux, FRANCE
Gollier-Briant, Fanny; Department of Pediatric Radiology, Necker-Enfants Malades Hospital, AP-HP, Université Paris Cité, Imagine Institute, Paris, FRANCE
Fossati, Philippe; Control-Interoception-Attention Team, Hôpital Pitié-Salpêtrière Paris, Brain Institute, Inserm/CNRS/Sorbonne University, Paris, FRANCE
Schmidt, Liane; Control-Interoception-Attention Team, Hôpital Pitié-Salpêtrière Paris, Brain Institute, Inserm/CNRS/Sorbonne University, Paris, FRANCE
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, GERMANY
Barker, Gareth J; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
Bokde, Arun L W; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Desrivières, Sylvane; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, SGDP Centre, King's College London, London, UK
Grigis, Antoine; NeuroSpin, CEA, Université Paris-Saclay, Gif-Sur-Yvette, FRANCE
Martinot, Jean-Luc; Institut National de La Santé Et de La Recherche Médicale, INSERM U 1299 “Trajectoires Développementales and Psychiatrie”, University Paris-Saclay, CNRS, Ecole Normale Supérieure Paris-Saclay, Centre Borelli, Gif-Sur-Yvette, FRANCE
Paillère Martinot, Marie-Laure; Institut National de La Santé Et de La Recherche Médicale, INSERM U 1299 “Trajectoires Développementales and Psychiatrie”, University Paris-Saclay, CNRS, Ecole Normale Supérieure Paris-Saclay, Gif-Sur-Yvette, FRANCE; Department of Child and Adolescent Psychiatry, AP-HP. Sorbonne University, Pitié-Salpêtrière Hospital, Paris, FRANCE
Artiges, Eric; Institut National de La Santé Et de La Recherche Médicale, INSERM U 1299 “Trajectoires Développementales and Psychiatrie”, University Paris-Saclay, CNRS, Ecole Normale Supérieure Paris-Saclay, Gif-Sur-Yvette, FRANCE; Psychiatry Department, EPS Barthélémy Durand, Etampes, FRANCE
Nees, Frauke; Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, GERMANY; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, GERMANY
Papadopoulos Orfanos, Dimitri; NeuroSpin, CEA, Université Paris-Saclay, Gif-Sur-Yvette, FRANCE
Poustka, Luise; Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, GERMANY
Hohmann, Sarah; Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Medical Center Hamburg-Eppendorf, Hamburg, GERMANY
Holz, Nathalie; Department of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, GERMANY
Fröhner, Juliane H.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Smolka, Michael N.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Vaidya, Nilakshi; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Berlin, GERMANY
Walter, Henrik; Department of Psychiatry and Psychotherapy CCM, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Whelan, Robert; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, Gunter; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Berlin, GERMANY; Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Lemaitre, Hervé; Institut Des Maladies Neurodégénératives, UMR 5293, CNRS, CEA, Université de Bordeaux, Bordeaux, FRANCE
Vulser, Hélène; Control-Interoception-Attention Team, Hôpital Pitié-Salpêtrière Paris, Brain Institute, Inserm/CNRS/Sorbonne University, Paris, FRANCE; Department of Adult Psychiatry, Centre du Neurodéveloppement Adulte, AP-HP.Sorbonne Université, Pitié-Salpêtrière Hospital, Paris, FRANCE
IMAGEN Consortium,
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| Quelle/Jahr | Brain Structure and Function:(2023), 229, 15 - 29 |
| ISSN | 1863-2653 (print) ; 1863-2661 (online) |
| DOI | |
| Verlag | Berlin ; Heidelberg: Springer |
| Zusammenfassung | A growing number of evidence supports a continued distribution of autistic traits in the general population. However, brain maturation trajectories of autistic traits as well as the influence of sex on these trajectories remain largely unknown. We investigated the association of autistic traits in the general population, with longitudinal gray matter (GM) maturation trajectories during the critical period of adolescence. We assessed 709 community-based adolescents (54.7% women) at age 14 and 22. After testing the effect of sex, we used whole-brain voxel-based morphometry to measure longitudinal GM volumes changes associated with autistic traits measured by the Social Responsiveness Scale (SRS) total and sub-scores. In women, we observed that the SRS was associated with slower GM volume decrease globally and in the left parahippocampus and middle temporal gyrus. The social communication sub-score correlated with slower GM volume decrease in the left parahippocampal, superior temporal gyrus, and pallidum; and the social cognition sub-score correlated with slower GM volume decrease in the left middle temporal gyrus, the right ventromedial prefrontal and orbitofrontal cortex. No longitudinal association was found in men. Autistic traits in young women were found to be associated with specific brain trajectories in regions of the social brain and the reward circuit known to be involved in Autism Spectrum Disorder. These findings support both the hypothesis of an earlier GM maturation associated with autistic traits in adolescence and of protective mechanisms in women. They advocate for further studies on brain trajectories associated with autistic traits in women. |
Zitierung
Gros, G., Marcos, R. M., Saitovitch, A., Gollier-Briant, F., Fossati, P., Schmidt, L., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Desrivières, S., Grigis, A., Brühl, R., Martinot, J.-L., Paillère Martinot, M.-L., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Poustka, L., Hohmann, S., Holz, N., Fröhner, J. H., Smolka, M. N., Vaidya, N., Walter, H., Whelan, R., Schumann, G., Lemaitre, H., Vulser, H., & IMAGEN Consortium. (2023). Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood. Brain Structure and Function, 15–29. https://doi.org/10.1007/s00429-023-02710-2