| Zugriffsnummer | 52884 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits |
| Autor(in); Institution |
Xue, Kaizhong; Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, CHINA
Gao, Bo; Department of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, CHINA
Chen, Feng; Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, CHINA
Wang, Meiyun; Department of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, CHINA
Cheng, Jingliang; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, CHINA
Zhang, Bing; Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, CHINA
Zhu, Wenzhen; Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, CHINA
Qiu, Shijun; Department of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, CHINA
Geng, Zuojun; Department of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, CHINA
Zhang, Xiaochu; Division of Life Science and Medicine, University of Science & Technology of China, Hefei, CHINA
Cui, Guangbin; Functional and Molecular Imaging Key Lab of Shaanxi Province & Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, CHINA
Martinot, Jean-Luc; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 “Trajectoires développementales & psychiatrie”, University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli, Gif-sur-Yvette, FRANCE
Paillère Martinot, Marie-Laure; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 “Trajectoires développementales & psychiatrie”, University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli, Gif-sur-Yvette, FRANCE; AP-HP. Sorbonne University, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, FRANCE
Artiges, Eric; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 “Trajectoires développementales & psychiatrie”, University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli, Gif-sur-Yvette, FRANCE; Psychiatry Department, EPS Barthélémy Durand, Etampes, FRANCE
Nees, Frauke; Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, GERMANY
Papadopoulos Orfanos, Dimitri; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Lemaitre, Herve; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE; Institut des Maladies Neurodégénératives, UMR 5293, CNRS, CEA, Université de Bordeaux, Bordeaux, FRANCE
Poustka, Luise; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Hohmann, Sarah; Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Medical Center Hamburg-Eppendorf, Hamburg, GERMANY
Holz, Nathalie; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Fröhner, Juliane H.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Smolka, Michael N.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Vaidya, Nilakshi; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Berlin, GERMANY
Walter, Henrik; Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Whelan, Robert; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Miao, Yanwei; Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, CHINA
Yu, Chunshui; Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, CHINA; CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, CHINA
IMAGEN Consortium,
CHIMGEN Consortium,
|
| Quelle/Jahr | Molecular Psychiatry: 28 (2023), 4853 - 4866 |
| ISSN | 1359-4184 (print) ; 1476-5578 (online) |
| DOI | |
| Verlag | Basingstoke: Nature Publishing Group |
| Zusammenfassung | Exposure to preadult environmental exposures may have long-lasting effects on mental health by affecting the maturation of the brain and personality, two traits that interact throughout the developmental process. However, environment-brain-personality covariation patterns and their mediation relationships remain unclear. In 4297 healthy participants (aged 18–30 years), we combined sparse multiple canonical correlation analysis with independent component analysis to identify the three-way covariation patterns of 59 preadult environmental exposures, 760 adult brain imaging phenotypes, and five personality traits, and found two robust environment-brain-personality covariation models with sex specificity. One model linked greater stress and less support to weaker functional connectivity and activity in the default mode network, stronger activity in subcortical nuclei, greater thickness and volume in the occipital, parietal and temporal cortices, and lower agreeableness, consciousness and extraversion as well as higher neuroticism. The other model linked higher urbanicity and better socioeconomic status to stronger functional connectivity and activity in the sensorimotor network, smaller volume and surface area and weaker functional connectivity and activity in the medial prefrontal cortex, lower white matter integrity, and higher openness to experience. We also conducted mediation analyses to explore the potential bidirectional mediation relationships between adult brain imaging phenotypes and personality traits with the influence of preadult environmental exposures and found both environment-brain-personality and environment-personality-brain pathways. We finally performed moderated mediation analyses to test the potential interactions between macro- and microenvironmental exposures and found that one category of exposure moderated the mediation pathways of another category of exposure. These results improve our understanding of the effects of preadult environmental exposures on the adult brain and personality traits and may facilitate the design of targeted interventions to improve mental health by reducing the impact of adverse environmental exposures. |
Zitierung
Xue, K., Gao, B., Chen, F., Wang, M., Cheng, J., Zhang, B., Zhu, W., Qiu, S., Geng, Z., Zhang, X., Cui, G., Brühl, R., Martinot, J.-L., Paillère Martinot, M.-L., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Lemaitre, H., Poustka, L., Hohmann, S., Holz, N., Fröhner, J. H., Smolka, M. N., Vaidya, N., Walter, H., Whelan, R., Miao, Y., Yu, C., IMAGEN Consortium, & CHIMGEN Consortium. (2023). Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits. Molecular Psychiatry, 28, 4853–4866. https://doi.org/10.1038/s41380-023-02261-2