Dopamine and deep brain stimulation accelerate the neural dynamics of volitional action in Parkinson’s disease
Autor(in); Institution
Köhler, Richard M.; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY
Binns, Thomas S.; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY; Einstein Center for Neurosciences Berlin, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY; Bernstein Center for Computational Neuroscience, Berlin, GERMANY
Merk, Timon; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY
Zhu, Guanyu; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University , Beijing, CHINA; Beijing Key Laboratory of Neurostimulation , Beijing, CHINA
Yin, Zixiao; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University , Beijing, CHINA; Beijing Key Laboratory of Neurostimulation , Beijing, CHINA
Zhao, Baotian; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University , Beijing, CHINA; Beijing Key Laboratory of Neurostimulation , Beijing, CHINA
Chikermane, Meera; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY
Vanhoecke, Jojo; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY
Busch, Johannes L.; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY
Habets, Jeroen G V; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY
Faust, Katharina; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY
Schneider, Gerd-Helge; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY
Cavallo, Alessia; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY
Haufe, Stefan; 8.4, Mathematische Modellierung und Datenanalyse, PTB-Berlin; Computer Science Department, Technische Universität Berlin, Berlin, GERMANY; Berlin Center for Advanced Neuroimaging (BCAN), Charité -Universitätsmedizin Berlin, Berlin, GERMANY
The ability to initiate volitional action is fundamental to human behaviour. Loss of dopaminergic neurons in Parkinson's disease is associated with impaired action initiation, also termed akinesia. Both dopamine and subthalamic deep brain stimulation (DBS) can alleviate akinesia, but the underlying mechanisms are unknown. An important question is whether dopamine and DBS facilitate de novo build-up of neural dynamics for motor execution or accelerate existing cortical movement initiation signals through shared modulatory circuit effects. Answering these questions can provide the foundation for new closed-loop neurotherapies with adaptive DBS, but the objectification of neural processing delays prior to performance of volitional action remains a significant challenge.
To overcome this challenge, we studied readiness potentials and trained brain signal decoders on invasive neurophysiology signals in 25 DBS patients (12 female) with Parkinson’s disease during performance of self-initiated movements. Combined sensorimotor cortex electrocorticography (ECoG) and subthalamic local field potential (LFP) recordings were performed OFF therapy (N = 22), ON dopaminergic medication (N = 18) and ON subthalamic deep brain stimulation (N = 8). This allowed us to compare their therapeutic effects on neural latencies between the earliest cortical representation of movement intention as decoded by linear discriminant analysis classifiers and onset of muscle activation recorded with electromyography (EMG).
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Open Access Hybrid
Rechteinformation
CC BY 4.0 ; Creative Commons Attribution 4.0 License
Themenbereich der Metrologie
Metrologie in der Medizin
Zitierung
Köhler, R. M., Binns, T. S., Merk, T., Zhu, G., Yin, Z., Zhao, B., Chikermane, M., Vanhoecke, J., Busch, J. L., Habets, J. G. V., Faust, K., Schneider, G.-H., Cavallo, A., Haufe, S., & et all. (2024). Dopamine and deep brain stimulation accelerate the neural dynamics of volitional action in Parkinson’s disease. Brain, 147(10), 3358–3369. https://doi.org/10.1093/brain/awae219
