| Zugriffsnummer | 52640 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Reliable biological and multi‑omics research through biometrology |
| Autor(in); Institution |
Dong, Lianhua; National Institute of Metrology (NIM), Beijing, CHINA
Zhang, Yu; National Institute of Metrology (NIM), Beijing, CHINA
Fu, Boqiang; National Institute of Metrology (NIM), Beijing, CHINA
Swart, Claudia; 3.2, Biochemie, PTB-Braunschweig
Jiang, Huayan; BGI, BGI-Shenzhen, Shenzhen, CHINA
Liu, Yahui; National Institute of Metrology (NIM), Beijing, CHINA
Huggett, Jim; National Measurement Laboratory at LGC (NML), Teddington, UK
Wielgosz, Robert; Bureau International Des Poids Et Mesures (BIPM), Sevres Cedex, FRANCE
Niu, Chunyan; National Institute of Metrology (NIM), Beijing, CHINA
Li, Qianyi; BGI, BGI-Shenzhen, Shenzhen, CHINA
Zhang, Yongzhuo; National Institute of Metrology (NIM), Beijing, CHINA
Park, Sang-Ryoul; Korea Research Institute of Standards and Science, Daejeon, REPUBLIC OF KOREA
Sui, Zhiwei; National Institute of Metrology (NIM), Beijing, CHINA
Yu, Lianchao; National Institute of Metrology (NIM), Beijing, CHINA
Liu, Yangyang; BGI, BGI-Shenzhen, Shenzhen, CHINA
Xie, Qing; BGI, BGI-Shenzhen, Shenzhen, CHINA
Zhang, Hongfu; BGI Genomics, BGI-Shenzhen, Shenzhen, CHINA
Yang, Yueyuxiao; MGI, BGI-Shenzhen, Shenzhen, CHINA
Dai, Xinhua; National Institute of Metrology (NIM), Beijing, CHINA
Shi, Leming; State Key Laboratory of Genetic Engineering
Yin, Ye; BGI, BGI-Shenzen, Shenzen, CHINA
Fang, Xiang; National Institute of Metrology (NIM), Beijing, CHINA
|
| Quelle/Jahr | Analytical and Bioanalytical Chemistry: 416 (2024), 3645 - 3663 |
| ISSN | 1618-2642 (print) ; 1618-2650 (online) |
| DOI | |
| Verlag | Berlin: Springer |
| Freie Schlagworte | Biometrology ; Reference materials ; Measurement uncertainty ; Metrological traceability ; Multi-omics ; Reproducibility |
| Zusammenfassung | Metrology is the science of measurement and its applications, whereas biometrology is the science of biological measurement and its applications. Biometrology aims to achieve accuracy and consistency of biological measurements by focusing on the development of metrological traceability, biological reference measurement procedures, and reference materials. Irreproducibility of biological and multi-omics research results from different laboratories, platforms, and analysis methods is hampering the translation of research into clinical uses and can often be attributed to the lack of biologists’ attention to the general principles of metrology. In this paper, the progresses of biometrology including metrology on nucleic acid, protein, and cell measurements and its impacts on the improvement of reliability and comparability in biological research are reviewed. Challenges in obtaining more reliable biological and multi-omics measurements due to the lack of primary reference measurement procedures and new standards for biological reference materials faced by biometrology are discussed. In the future, in addition to establishing reliable reference measurement procedures, developing reference materials from single or multiple parameters to multi-omics scale should be emphasized. Thinking in way of biometrology is warranted for facilitating the translation of high-throughput omics research into clinical practices. |
| Themenbereich der Metrologie | Metrologie in der Medizin |
| Förderinformationen (1) |
Förderer ID Typ: ISNI |
Zitierung
Dong, L., Zhang, Y., Fu, B., Swart, C., Jiang, H., Liu, Y., Huggett, J., Wielgosz, R., Niu, C., Li, Q., Zhang, Y., Park, S.-R., Sui, Z., Yu, L., Liu, Y., Xie, Q., Zhang, H., Yang, Y., Dai, X., Shi, L., Yin, Y., & Fang, X. (2024). Reliable biological and multi‑omics research through biometrology. Analytical and Bioanalytical Chemistry, 416, 3645–3663. https://doi.org/10.1007/s00216-024-05239-3