| Zugriffsnummer | 52206 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Combination of standard addition and isotope dilution mass spectrometry for the accurate determination of melamine and cyanuric acid in infant formula |
| Autor(in); Institution |
Pedan, Vasilisa; Sigma-Aldrich Production GmbH (Subsidiary of Merck KGaA), Buchs, SWITZERLAND
Koehling, Rudolf; Sigma-Aldrich Production GmbH (Subsidiary of Merck KGaA), Buchs, SWITZERLAND
Drexel, Lukas; Sigma-Aldrich Production GmbH (Subsidiary of Merck KGaA), Buchs, SWITZERLAND
Breitruck, Kathrin; Sigma-Aldrich Production GmbH (Subsidiary of Merck KGaA), Buchs, SWITZERLAND
Rueck, Alexander; Sigma-Aldrich Production GmbH (Subsidiary of Merck KGaA), Buchs, SWITZERLAND
Rohn, Sascha; Institute of Food Technology and Food Chemistry, Department of Food Chemistry and Analysis, Technische Universität Berlin, Berlin, GERMANY
Seidel, Tim; Sigma-Aldrich Production GmbH (Subsidiary of Merck KGaA), Buchs, SWITZERLAND
Allenspach, Eric; Sigma-Aldrich Production GmbH (Subsidiary of Merck KGaA), Buchs, SWITZERLAND
Obkircher, Markus; Sigma-Aldrich Production GmbH (Subsidiary of Merck KGaA), Buchs, SWITZERLAND
|
| Quelle/Jahr | Application of Chromatography/Mass Spectrometry in Food Quality and Food Safety. Foods: 13 (2024), 15, 1 - 17 |
| Artikelnummer | 2377 |
| Availability | [online only] |
| ISSN | 2304-8158 (online) |
| DOI | |
| Verlag | Basel: MDPI |
| Freie Schlagworte | isotope dilution mass spectrometry ; proficiency testing ; infant formula ; two-dimensional liquid chromatography ; residues |
| Zusammenfassung | In the melamine scandals of the early 2000s, different companies of the dairy industry cheated their products by applying chemical substances to feign a higher content of nitrogen. However, this had a severe toxic impact on the kidney health of consumers. As a result, tremendous effort was put into the prevention of further harm to the public. In the present study, a fast–screening method for the determination of melamine and cyanuric acid in infant formula was developed. While a 1D-LC approach is faster and easier to set up, a 2D-LC approach allows for a more accurate result with better selectivity and sensitivity. For both instrumental approaches, the signal ratio of the isotopologues was crucial and had a dominant effect on the results and the measurement uncertainty. For this reason, the different contributions to the measurement uncertainty were determined experimentally using Matched Standard Addition-IDMS and compared to the Exact Matching Double IDMS. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Chemie und Stoffeigenschaften |
Zitierung
Pedan, V., Koehling, R., Drexel, L., Breitruck, K., Rueck, A., Rohn, S., Rienitz, O., Pramann, A., Seidel, T., Allenspach, E., & Obkircher, M. (2024). Combination of standard addition and isotope dilution mass spectrometry for the accurate determination of melamine and cyanuric acid in infant formula. Foods, 13(15), 1–17. https://doi.org/10.3390/foods13152377