| Zugriffsnummer | 52149 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Nanodosimetry applied to aerobic and hypoxic cells |
| Autor(in); Institution |
Conte, Valeria; INFN Laboratori Nazionali di Legnaro (LNL), Legnaro, ITALY
Bianchi, Anna; IINFN Laboratori Nazionali di Legnaro (LNL), Legnaro, ITALY
Selva, Anna; INFN Laboratori Nazionali di Legnaro (LNL), Legnaro, ITALY
|
| Quelle/Jahr | Radiation Physics and Chemistry: 222 (2024), 1 - 6 |
| Artikelnummer | 111835 |
| ISSN | 0969-806X (print) |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Freie Schlagworte | Nanodosimetry ; Radiobiology ; Ion beam therapy |
| Zusammenfassung | The biological response to light ion irradiation is influenced by complex DNA damage, which is closely associated with the particle track structure. This study aims to explore the correlation between nanoscale ionization distribution and the likelihood of inducing cell death in both aerobic and hypoxic cells. Monte Carlo track-structure simulations were conducted for protons, helium, carbon, and neon ions of various energies, interacting with a gaseous spherical target volume with a water equivalent diameter of 1 nm. The simulations employed the MC-Startrack code, which accurately reproduces the experimental response of the Startrack counter, the nanodosimeter developed at the Legnaro National Laboratories of INFN. The primary particles were directed through the centre of the sphere, with impact parameters set to zero. The link to radiobiology was explored. The results reveal significant correlations between the inactivation cross sections reported by Furusawa, for both aerobic and hypoxic cells, and linear combinations of cumulative probabilities of measuring more than 1, 2 or 3 ionizations. The proportionality factor, unique to each cell line, represents the saturation value of biological cross sections. |
