Computational Dosimetry ; Monte Carlo ; EURADOS ; Nanoparticles ; PTB high performance compute cluster
Zusammenfassung
In vitro and in vivo experiments showed that gold nanoparticles (GNPs) enhance radiation effects to tumours in mice and demonstrated a high potential of GNPs for clinical application. This enhanced biological effectiveness is often attributed to the enhanced energy deposition in the vicinity of the GNP by secondary electrons around GNPs, particularly by short-ranged Auger electrons. However, this energy deposition is difficult to measure. Computational approaches, such as Monte Carlo (MC) radiation transport simulations, are used to estimate the dosimetric effects of GNPs, where results differing by orders of magnitudes have been reported by different investigators. This has motivated an intercomparison exercise, which was conducted as a joint activity of EURADOS Working Groups 6 “Computational Dosimetry” and 7 “Internal Dosimetry”.
Several individual EURADOS associate members and two code developer groups from outside Europe participated in this exercise applying seven different MC codes to perform the simulations of a simple defined geometry set-up of one single GNP irradiated in water by kilo-voltage X-rays. Two GNP diameters of 50 nm and 100 nm of were considered and two photon spectra as generated by X-ray tubes operated at 50 kV and 100 kV peak voltages. The geometry set-up and X-ray spectra were provided by the EURADOS task group. The participants were asked to determine for each combination of GNP size and X-ray spectrum the dose enhancement ratio (DER) of 10 nm-thick water shells up to 1000 nm and 1 μm-thick water shells up to 50 μm around the GNP. Furthermore, the electron spectra emitted from the GNP and the energy depositions in water shells around it were also to be reported.
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Zitierung
Li, W. B., Rabus, H., Villagrasa, C., & Schuemann, J. (2024). Intercomparison exercise on Monte Carlo simulations of electron spectra and energy depositions by a single gold nanoparticle under X-ray irradiation. https://doi.org/10.12768/zw0r-6z73
