| Zugriffsnummer | 51683 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Repair Kinetics of DSB-Foci Induced by Proton and α-Particle Microbeams of Different Energies |
| Autor(in); Institution |
Belchior, Ana; Universidade de Lisboa, Instituto Superior Técnico, Centro de Ciências e Tecnologias Nucleares, Bobadela, PORTUGAL
Canhoto, João F.; Universidade de Lisboa, Instituto Superior Técnico, Centro de Ciências e Tecnologias Nucleares, Bobadela, PORTUGAL; Universidade de Lisboa, Instituto Superior Técnico, Departamento de Física, Lisboa, PORTUGAL
Langner, Frank; 6.4, Neutronenstrahlung, PTB-Braunschweig
Schulte, Reinhard; Division of Biomedical Engineering Sciences, Loma Linda University, Loma Linda, CA, USA
|
| Quelle/Jahr | Ionizing Radiation of High LET and DNA Damage Responses. Life: 12 (2022), 12, 36-1 - 36-2 |
| Artikelnummer | 2040 |
| Availability | [online only] |
| ISSN | 2075-1729 (online) |
| DOI | |
| Verlag | Basel: MDPI |
| Freie Schlagworte | radiation-induced foci ; track structure ; DNA damage repair |
| Zusammenfassung | In this work, the induction and repair of radiation-induced 53BP1 foci were studied in human umbilical vein endothelial cells irradiated at the PTB microbeam with protons and α-particles of different energies. The data were analyzed in terms of the mean number of 53BP1 foci induced by the different ion beams. The number of 53BP1 foci found at different times post-irradiation suggests that the disappearance of foci follows first order kinetics. The mean number of initially produced foci shows the expected increase with LET. The most interesting finding of this work is that the absolute number of persistent foci increases with LET but not their fraction. Furthermore, protons seem to produce more persistent foci as compared to α-particles of even higher LET. This may be seen as experimental evidence that protons may be more effective in producing severe DNA lesions, as was already shown in other work, and that LET may not be the best suited parameter to characterize radiation quality. |
| Relation |
https://doi.org/10.3390/life14010036 – (Correction: Life 2024, 14(1), 36)
|
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Förderinformationen (1) |
Förderername: Fundação para a Ciência e a Tecnologia (FCT)
Förderer ID: 0000 0001 2169 9189 Förderer ID Typ: ISNI Förderprogramm: European Metrology Research Program (EMRP) Titel der Förderung: BioQuaRT Förderungsnummer: PRT/BD/151544/2021 ; SIB06-REG3 |