| Zugriffsnummer | 51595 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | 13C MRI of hyperpolarized pyruvate at 120 μT |
| Autor(in); Institution |
Kempf, N.; High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, GERMANY
Plaumann, M.; Institute for Molecular Biology and Medicinal Chemistry, Medical Faculty, Otto-von-Guericke University, Magdeburg, GERMANY
Pravdivtsev, A. N.; Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center, Kiel University, Kiel, GERMANY
Engelmann, J.; High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, GERMANY
Boldt, J.; High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, GERMANY
Scheffler, K.; High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, GERMANY; Departement of Biomedical Magnetic Resonance, Eberhard-Karls University, Tübingen, GERMANY
Theis, T.; High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, GERMANY; Departement of Chemistry and Physics, NC State University, Raleigh, USA
Buckenmaier, K.; High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, GERMANY
|
| Quelle/Jahr | Scientific Reports: 14 (2024), 1 - 7 |
| Artikelnummer | 4468 |
| Availability | [online only] |
| ISSN | 2045-2322 (online) |
| DOI | |
| Verlag | London: Nature Publishing Group |
| Zusammenfassung | Nuclear spin hyperpolarization increases the sensitivity of magnetic resonance dramatically, enabling many new applications, including real-time metabolic imaging. Parahydrogen-based signal amplification by reversible exchange (SABRE) was employed to hyperpolarize [1-13C]pyruvate and demonstrate 13C imaging in situ at 120 μT, about twice Earth’s magnetic field, with two different signal amplification by reversible exchange variants: SABRE in shield enables alignment transfer to heteronuclei (SABRE- HEATH), where hyperpolarization is transferred from parahydrogen to [1-13C] pyruvate at a magnetic field below 1 μT, and low-irradiation generates high tesla (LIGH-SABRE), where hyperpolarization was prepared at 120 μT, avoiding magnetic field cycling. The 3- dimensional images of a phantom were obtained using a superconducting quantum interference device (SQUID) based magnetic field detector with submillimeter resolution. These 13C images demonstrate the feasibility of low-field 13C metabolic magnetic resonance imaging (MRI) of 50 mM [1-13C]pyruvate hyperpolarized by parahydrogen in reversible exchange imaged at about twice Earth’s magnetic field. Using thermal 13C polarization available at 120 μT, the same experiment would have taken about 300 billion years. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
| Förderinformationen (1) |
Förderername: Bundesministerium für Bildung und Forschung (BMBF)
Förderer ID: 0000 0000 9090 0344 Förderer ID Typ: ISNI Förderprogramm: Projekt DEAL Förderungsnummer: Grant 01ZX1915C (ANP) |