| Zugriffsnummer | 51560 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Hemispheric asymmetry in cortical thinning reflects intrinsic organization of the neurotransmitter systems and homotopic functional connectivity |
| Autor(in); Institution |
Liao, Zhijie; Research Centre of Sainte-Justine University Hospital, Montreal, CANADA; Department of Psychiatry and Addictology, University of Montreal, Montreal, CANADA
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, Arun L.W.; Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, IRELAND; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Desrivières, Sylvane; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic & Developmental Psychiatry Centre, King's College London, London, UNITED KINGDOM
Flor, Herta; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Antoine, Grigis; NeuroSpin, Energies and Atomic Energy Commission, Université Paris-Saclay, Paris, FRANCE
Garavan, Hugh; Department of Psychiatry, University of Vermont, Burlington, VT, USA; Department of Psychology, University of Vermont, Burlington, VT, USA
Gowland, Penny; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, UNITED KINGDOM
Heinz, Andreas; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Martinot, Jean-Luc; Institut National de la Santé et de la Recherche Médicale, INSERM "Developmental trajectories & psychiatry" Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Paris 75006, FRANCE
Paillère Martinot, Marie-Laure; Institut National de la Santé et de la Recherche Médicale, INSERM "Developmental trajectories & psychiatry" Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Paris 75006, FRANCE; Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, AP-HP.Sorbonne Université, Paris, FRANCE
Artiges, Eric; Institut National de la Santé et de la Recherche Médicale, INSERM "Developmental trajectories & psychiatry" Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Paris 75006, FRANCE; Etablissement Public de Santé Barthélemy Durand, Paris, FRANCE
Nees, Frauke; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, GERMANY
Papadopouos Orfanos, Dimitri; NeuroSpin, Energies and Atomic Energy Commission, Université Paris-Saclay, Paris, FRANCE
Poustka, Luise; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Hohmann, Sarah; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Millenet, Sabina; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Fröhner, Juliane H.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Smolka, Michael N.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Walter, Henrik; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin 10117, GERMANY
Whelan, Robert; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, Gunter; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Institute for Science and Technology of Brain-inspired Intelligence, Fudan University, Shanghai, Peoples Republic of CHINA; Centre for Population Neuroscience and Precision Medicine, Charite Universitätsmedizin Berlin, Berlin, GERMANY
Paus, Tomáš; Research Centre of Sainte-Justine University Hospital, Montreal, QC, CANADA; Department of Psychiatry and Addictology, University of Montreal, Montreal, QC, CANADA; Department of Neuroscience, University of Montreal, Montreal, QC, CANADA
IMAGEN consortium,
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| Quelle/Jahr | Proceedings of the National Academy of Sciences of the United States of America: 120 (2023), 42, 1 - 9 |
| Artikelnummer | e2306990120 |
| ISSN | 0027-8424 (print) ; 1091-6490 (online) |
| DOI | |
| Verlag | Washington, DC: PNAS |
| Freie Schlagworte | adolescence ; cortical thickness ; hemispheric asymmetry ; neurotransmitters; plasticity |
| Zusammenfassung | Hemispheric lateralization and its origins have been of great interest in neuroscience for over a century. The left–right asymmetry in cortical thickness may stem from differential maturation of the cerebral cortex in the two hemispheres. Here, we investigated the spatial pattern of hemispheric differences in cortical thinning during adolescence, and its relationship with the density of neurotransmitter receptors and homotopic functional connectivity. Using longitudinal data from IMAGEN study (N = 532), we found that many cortical regions in the frontal and temporal lobes thinned more in the right hemisphere than in the left. Conversely, several regions in the occipital and parietal lobes thinned less in the right (vs. left) hemisphere. We then revealed that regions thinning more in the right (vs. left) hemispheres had higher density of neurotransmitter receptors and transporters in the right (vs. left) side. Moreover, the hemispheric differences in cortical thinning were predicted by homotopic functional connectivity. Specifically, regions with stronger homotopic functional connectivity showed a more symmetrical rate of cortical thinning between the left and right hemispheres, compared with regions with weaker homotopic functional connectivity. Based on these findings, we suggest that the typical patterns of hemispheric differences in cortical thinning may reflect the intrinsic organization of the neurotransmitter systems and related patterns of homotopic functional connectivity. |
Zitierung
Liao, Z., Banaschewski, T., Bokde, A. L., Desrivières, S., Flor, H., Antoine, G., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Paillère Martinot, M.-L., Artiges, E., Nees, F., Papadopouos Orfanos, D., Poustka, L., Hohmann, S., Millenet, S., Fröhner, J. H., Smolka, M. N., Walter, H., Whelan, R., Schumann, G., Paus, T., & IMAGEN consortium. (2023). Hemispheric asymmetry in cortical thinning reflects intrinsic organization of the neurotransmitter systems and homotopic functional connectivity. Proceedings of the National Academy of Sciences of the United States of America, 120(42), 1–9. https://doi.org/10.1073/pnas.2306990120