Toward accurate and fast velocity quantification with 3D ultrashort TE phase-contrast imaging
Autor(in); Institution
Degenhardt, Katja; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin; Department of Radiology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY
Schmidt, Simon; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA Humboldt-Universität zu Berlin, Berlin, GERMANY; Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, GERMANY
Aigner, Christoph Stefan; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Kratzer, Fabian J.; Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, GERMANY
Seiter, Daniel P.; Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Department of Medical Physics, University ofWisconsin, Madison, Wisconsin, USA
Mueller, Max; Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GERMANY
Nagel, Armin M.; Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, GERMANY; Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GERMANY
Wieben, Oliver; Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA; Department of Radiology, University of Wisconsin Madison, Madison, Wisconsin, USA
Schäffter, Tobias; 8, Medizinphysik und Metrologische Informationstechnik, PTB-Berlin; School of Imaging Science and Biomedical Engineering, King’s College London, London, United Kingdom; Department of Medical Engineering, Technical University of Berlin, Berlin, GERMANY
Schulz-Menger, Jeanette; Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GERMANY; Working Group on CardiovascularMagnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine, Berlin, GERMANY; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, GERMANY
Schmitter, Sebastian; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA; Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, GERMANY
Quelle/Jahr
Magnetic Resonance in Medicine: 91
(2024), 5, 1994
- 2009
Purpose: Traditional phase-contrast MRI is affected by displacement artifacts caused by non-synchronized spatial- and velocity-encoding time points. The resulting inaccurate velocity maps can affect the accuracy of derived hemodynamic parameters. This study proposes and characterizes a 3D radial phase-contrast UTE (PC-UTE) sequence to reduce displacement artifacts. Furthermore, it investigates the displacement of a standard Cartesian flow sequence by utilizing a displacement-free synchronized-single-point imaging MR sequence (SYNC-SPI) that requires clinically prohibitively long acquisition times.
Methods: 3D flow data was acquired at 3T at three different constant flow rates and varying spatial resolutions in a stenotic aorta phantom using the proposed PC-UTE, a Cartesian flow sequence, and a SYNC-SPI sequence as reference. Expected displacement
artifacts were calculated from gradient timing waveforms and compared to displacement values measured in the in vitro flow experiments.
Results: The PC-UTE sequence reduces displacement and intravoxel dephasing, leading to decreased geometric distortions and signal cancellations in magnitude images, and more spatially accurate velocity quantification compared to the Cartesian flow acquisitions; errors increase with velocity and higher spatial resolution.
Conclusion: PC-UTE MRI can measure velocity vector fields with greater accuracy than Cartesian acquisitions (although pulsatile fields were not studied) and shorter scan times than SYNC-SPI. As such, this approach is superior to traditional Cartesian 3D and 4D flow MRI when spatial misrepresentations cannot be tolerated, for example, when computational fluid dynamics simulations are compared to or combined with in vitro or in vivo measurements, or regional parameters such as wall shear stress are of interest.
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Open Access Hybrid
Rechteinformation
CC BY 4.0 ; Creative Commons Attribution 4.0 License
Zitierung
Degenhardt, K., Schmidt, S., Aigner, C. S., Kratzer, F. J., Seiter, D. P., Mueller, M., Kolbitsch, C., Nagel, A. M., Wieben, O., Schäffter, T., Schulz-Menger, J., & Schmitter, S. (2024). Toward accurate and fast velocity quantification with 3D ultrashort TE phase-contrast imaging. Magnetic Resonance in Medicine, 91(5), 1994–2009. https://doi.org/10.1002/mrm.29978
