| Zugriffsnummer | 51024 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | In silico modelling of aortic strain and strain rate in aortic coarctation treated with stent angioplasty with comparison to clinical cohorts |
| Autor(in); Institution |
Gaddum, Nicholas; King's College London, Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, London, UK
Dillon-Murphy, Des; King's College London, Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, London, UK
Arm, Richard; Nottingham Trent University, College of Art & Design and Built Environment, School of Art & Design, Nottingham, UK
Rafiq, Isma; King's College London, Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, London, UK
Chabiniok, Radomir; King's College London, Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, London, UK
Morgan, Gareth; Evelina Children's Hospital, St Thomas’ Hospital, Westminster Bridge Road, London, UK
Schäffter, Tobias; 8, Medizinphysik und Metrologische Informationstechnik, PTB-Berlin
Hussain, Tarique; King's College London, Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, London, UK
|
| Quelle/Jahr | Applications in Engineering Science: 12 (2022), 1 - 9 |
| Artikelnummer | 100123 |
| Availability | [online only] |
| ISSN | 2666-4968 (online) |
| DOI | |
| Verlag | Amsterdam [u.a.]: Elsevier |
| Freie Schlagworte | coarctation ; stent angioplasty ; experimental model ; arterial modeling ; pressure ; arterial strain |
| Zusammenfassung | Objective Treatment of aortic coarctation has seen a shift from traditional surgical repair to the use of aortic stents. The aim of this study was to assess the impact upon hemodynamics and arterial strain when aortic coarctation is treated with a stent using an experimental coarctation model, and to confirm any findings in a clinical cohort using MRI. Methods An experimental patient model included a silicone arterial tree, and ventricular stroke profile was derived from patient MRI data. Pressure, flow and aortic strain was measured before and after stent placement in the model. A clinical study comprised of strain measurements using MRI in two patient cohorts; those treated with a stent, and those treated with surgical repair. Results Before stent placement, peak strain decreased as the pulse propagated away from the aortic valve. After stent placement however, peak strain was amplified as it approached the stent, despite peak systolic pressure having dropped by 20 mmHg. Introduction of the stent caused an almost three fold increase in aortic strain rate to 150%.s − 1. Echoing these results the stented patient group's strain increased from 28% +/- 14% in the ascending aorta to 43% +/- 24% (p < 0.05) pre-coarctation. This was not seen in those with surgical repair of coarctation, (ascending aorta 40% +/- 22% compared to the pre-coarctation aorta strain 38% +/- 20%, p = 0.81). Conclusions Despite a reduced systolic pressure gradient through a stented coarctation, dramatic increases in strain and strain rate could attribute subsequent pathologies in the aorta proximally. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
Zitierung
Gaddum, N., Dillon-Murphy, D., Arm, R., Rafiq, I., Chabiniok, R., Morgan, G., Schäffter, T., & Hussain, T. (2022). In silico modelling of aortic strain and strain rate in aortic coarctation treated with stent angioplasty with comparison to clinical cohorts. Applications in Engineering Science, 12, 1–9. https://doi.org/10.1016/j.apples.2022.100123