| Zugriffsnummer | 50835 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Differential associations of adolescent versus young adult cannabis initiation with longitudinal brain change and behavior |
| Autor(in); Institution |
Albaugh, M.; Department of Psychiatry, University of Vermont, Burlington, VT, USA
Owens, M.; Department of Psychiatry, University of Vermont, Burlington, VT, USA
Ottino-Gonzalez, J.; Department of Psychiatry, University of Vermont, Burlington, VT, USA
Cupertino, R.; Department of Psychiatry, University of Vermont, Burlington, VT, USA
Cao, Z.; Department of Psychiatry, University of Vermont, Burlington, VT, USA
Mackey, S.; Department of Psychiatry, University of Vermont, Burlington, VT, USA
Lepage, C.; McConnell Brain Imaging Centre, McGill University, Montreal, QC, CANADA
Rioux, P.; McConnell Brain Imaging Centre, McGill University, Montreal, QC, CANADA
Evans, A.; McConnell Brain Imaging Centre, McGill University, Montreal, QC, CANADA
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, A.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Conrod, P.; Department of Psychiatry, University of Montreal, Montreal, QC, CANADA
Desrivières, S.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK
Flor, H.; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, GERMANY; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Grigis, A.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Heinz, A.; Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Martinot, J.; Institut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales en psychiatrie", Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, FRANCE
Martinot, M.; Institut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales en psychiatrie"; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli; and AP-HP.Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, FRANCE
Artiges, E.; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 "Developmental trajectories & psychiatry""; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli; Gif-sur-Yvette; and Etablissement Public de Santé (EPS) Barthélemy Durand, Sainte-Geneviève-des-Bois, FRANCE
Nees, F.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, GERMANY; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, GERMANY; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, GERMANY
Orfanos, D.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Paus, T.; Departments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hospitaliere Universitaire Sainte-Justine, University of Montreal, Montreal, QC, CANADA; Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Millenet, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Fröhner, J.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Smolka, M.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, G.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK; PONS Research Group, Dept of Psychiatry and Psychotherapy, Campus Charite Mitte, Humboldt University, Berlin and Leibniz Institute for Neurobiology, Magdeburg, GERMANY; Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, P. R. CHINA
Potter, A.; Department of Psychiatry, University of Vermont, Burlington, VT, USA
Garavan, H.; Department of Psychiatry, University of Vermont, Burlington, VT, USA
IMAGEN Consortium,
|
| Quelle/Jahr | Molecular Psychiatry: 28 (2023), 5173 - 5182 |
| ISSN | 1359-4184 (print) ; 1476-5578 (online) |
| DOI | |
| Verlag | Basingstoke: Springer Nature |
| Zusammenfassung | Leveraging ~10 years of prospective longitudinal data on 704 participants, we examined the effects of adolescent versus young adult cannabis initiation on MRI-assessed cortical thickness development and behavior. Data were obtained from the IMAGEN study conducted across eight European sites. We identified IMAGEN participants who reported being cannabis-naïve at baseline and had data available at baseline, 5-year, and 9-year follow-up visits. Cannabis use was assessed with the European School Survey Project on Alcohol and Drugs. T1-weighted MR images were processed through the CIVET pipeline. Cannabis initiation occurring during adolescence (14-19 years) and young adulthood (19-22 years) was associated with differing patterns of longitudinal cortical thickness change. Associations between adolescent cannabis initiation and cortical thickness change were observed primarily in dorso- and ventrolateral portions of the prefrontal cortex. In contrast, cannabis initiation occurring between 19 and 22 years of age was associated with thickness change in temporal and cortical midline areas. Follow-up analysis revealed that longitudinal brain change related to adolescent initiation persisted into young adulthood and partially mediated the association between adolescent cannabis use and past-month cocaine, ecstasy, and cannabis use at age 22. Extent of cannabis initiation during young adulthood (from 19 to 22 years) had an indirect effect on psychotic symptoms at age 22 through thickness change in temporal areas. Results suggest that developmental timing of cannabis exposure may have a marked effect on neuroanatomical correlates of cannabis use as well as associated behavioral sequelae. Critically, this work provides a foundation for neurodevelopmentally informed models of cannabis exposure in humans. |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Albaugh, M., Owens, M., Ottino-Gonzalez, J., Cupertino, R., Cao, Z., Mackey, S., Lepage, C., Rioux, P., Evans, A., Banaschewski, T., Bokde, A., Conrod, P., Desrivières, S., Flor, H., Grigis, A., Gowland, P., Heinz, A., Ittermann, B., Martinot, J., Martinot, M., Artiges, E., Nees, F., Orfanos, D., Paus, T., Poustka, L., Millenet, S., Fröhner, J., Smolka, M., Walter, H., Whelan, R., Schumann, G., Potter, A., Garavan, H., & IMAGEN Consortium. (2023). Differential associations of adolescent versus young adult cannabis initiation with longitudinal brain change and behavior. Molecular Psychiatry, 28, 5173–5182. https://doi.org/10.1038/s41380-023-02148-2