| Zugriffsnummer | 50638 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | International comparison exercise for biological dosimetry after exposures with neutrons performed at two irradiation facilities as part of the BALANCE project |
| Autor(in); Institution |
Endesfelder, D.; Department of Effects and Risks of Ionising and Non-Ionising Radiation, Federal Office for Radiation Protection (BfS), Oberschleißheim, GERMANY
Kulka, U.; Department of Effects and Risks of Ionising and Non-Ionising Radiation, Federal Office for Radiation Protection (BfS), Oberschleißheim, GERMANY
Bucher, M.; Department of Effects and Risks of Ionising and Non-Ionising Radiation, Federal Office for Radiation Protection (BfS), Oberschleißheim, GERMANY
Giesen, Ulrich; 6.4, Neutronenstrahlung, PTB-Braunschweig
Garty, G.; Radiological Research Accelerator Facility (RARAF), Columbia University, Irvington, NY, USA
Beinke, C.; Bundeswehr Institute of Radiobiology, Munich, GERMANY
Port, M.; Bundeswehr Institute of Radiobiology, Munich, GERMANY
Gruel, G.; Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, FRANCE
Gregoire, E.; Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, FRANCE
Terzoudi, G.; Health Physics, Radiobiology & Cytogenetics Laboratory, National Centre for Scientific Research, Athens, GREECE
Triantopoulou, S.; Cytogenetics Laboratory, National Centre for Scientific Research, Athens, GREECE
Ainsbury, E.A.; Radiation, Chemicals and Environmental Hazards Directorate, UK Health Security Agency, Chilton, Oxfordshire, UK
Moquet, J.; Radiation, Chemicals and Environmental Hazards Directorate, UK Health Security Agency, Chilton, Oxfordshire, UK
Sun, M.; Radiation, Chemicals and Environmental Hazards Directorate, UK Health Security Agency, Chilton, Oxfordshire, UK
Jesus Prieto, M.; Centro de Oncología Radioterápica, Laboratorio de Dosimetría Biológica, Hospital General Universitario Gregorio Marañón, Madrid, SPAIN
Moreno Domene, M.; Centro de Oncología Radioterápica, Laboratorio de Dosimetría Biológica, Hospital General Universitario Gregorio Marañón, Madrid, SPAIN
Barquinero, J.-F.; Departament de Biologia Animal, Unitat d’Antropologia Biològica, Universitat Autònoma de Barcelona, Bellaterra, SPAIN
Pujol-Canadell, M.; Departament de Biologia Animal, Unitat d’Antropologia Biològica, Universitat Autònoma de Barcelona, Bellaterra, SPAIN
Vral, A.; Faculty of Medicine and Health Sciences, Department of Human Structure and Repair, Radiobiology Research Unit, Ghent University, Gent, BELGIUM
Baeyens, A.; Faculty of Medicine and Health Sciences, Department of Human Structure and Repair, Radiobiology Research Unit, Ghent University, Gent, BELGIUM
Wojcik, A.; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, SWEDEN; lnstitute of Biology, Jan Kochanowski University, Kielce, POLAND
Oestreicher, U.; Department of Effects and Risks of Ionising and Non-Ionising Radiation, Federal Office for Radiation Protection (BfS), Oberschleißheim, GERMANY
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| Quelle/Jahr | Cytogenetic and Genome Research:(2023), 1 - 15 |
| ISSN | 1424-8581 (print) ; 1424-859X (online) |
| DOI | |
| Verlag | Basel: Karger |
| Freie Schlagworte | Biological dosimetry ; RENEB ; Neutrons ; Dicentric chromosomes ; Biological effectiveness |
| Zusammenfassung | In the case of a radiological or nuclear event, biological dosimetry can be an important tool to support clinical decision-making. During a nuclear event, individuals might be exposed to a mixed field of neutrons and photons. The composition of the field and the neutron energy spectrum influence the degree of damage to the chromosomes. During the transatlantic BALANCE project, an exposure similar to a Hiroshima-like device at a distance of 1.5 km from the epicenter was simulated, and biological dosimetry based on dicentric chromosomes was performed to evaluate the participants ability to discover unknown doses and to test the influence of differences in neutron spectra. In a first step, calibration curves were established by irradiating blood samples with 5 doses in the range of 0-4 Gy at two different facilities in Germany (Physikalisch-Technische Bundesanstalt [PTB]) and the USA (the Columbia IND Neutron Facility [CINF]). The samples were sent to eight participating laboratories from the RENEB network and dicentric chromosomes were scored by each participant. Next, blood samples were irradiated with 4 blind doses in each of the two facilities and sent to the participants to provide dose estimates based on the established calibration curves. Manual and semiautomatic scoring of dicentric chromosomes were evaluated for their applicability to neutron exposures. Moreover, the biological effectiveness of the neutrons from the two irradiation facilities was compared. The calibration curves from samples irradiated at CINF showed a 1.4 times higher biological effectiveness compared to samples irradiated at PTB. For manual scoring of dicentric chromosomes, the doses of the test samples were mostly successfully resolved based on the calibration curves established during the project. For semiautomatic scoring, the dose estimation for the test samples was less successful. Doses >2 Gy in the calibration curves revealed nonlinear associations between dose and dispersion index of the dicentric counts, especially for manual scoring. The differences in the biological effectiveness between the irradiation facilities suggested that the neutron energy spectrum can have a strong impact on the dicentric counts. |
| Themenbereich der Metrologie | Ionisierende Strahlung |
| Innovationscluster | Gesundheit |
| Geschäftsfelder | Metrologie für die Gesellschaft |
| Forschungsprojekt | BALANCE |
| Förderinformationen (1) |
Förderername: National Institute of Allergy and Infectious Diseases (NIAID)
Förderer ID: 0000 0001 2164 9667 Förderer ID Typ: ISNI Förderungsnummer: U19-AI067773 |
| Förderinformationen (2) |
Förderername: National Institutes of Health (NIH)
Förderer ID: 0000 0001 1942 0345 Förderer ID Typ: ISNI |
Zitierung
Endesfelder, D., Kulka, U., Bucher, M., Giesen, U., Garty, G., Beinke, C., Port, M., Gruel, G., Gregoire, E., Terzoudi, G., Triantopoulou, S., Ainsbury, E., Moquet, J., Sun, M., Jesus Prieto, M., Moreno Domene, M., Barquinero, J.-F., Pujol-Canadell, M., Vral, A., Baeyens, A., Wojcik, A., & Oestreicher, U. (2023). International comparison exercise for biological dosimetry after exposures with neutrons performed at two irradiation facilities as part of the BALANCE project. Cytogenetic and Genome Research, 1–15. https://doi.org/10.1159/000530728