| Zugriffsnummer | 50448 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | A stable and replicable neural signature of lifespan adversity in the adult brain |
| Autor(in); Institution |
Holz, N.; Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, THE NETHERLANDS; Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, THE NETHERLANDS; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, GERMANY
Zabihi, M.; Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, THE NETHERLANDS; Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, THE NETHERLANDS; MRC Unit for Lifelong Health & Ageing, University College London (UCL), London, UK
Kia, S.; Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, THE NETHERLANDS; Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, THE NETHERLANDS; Department of Psychiatry, University Medical Center Utrecht, Utrecht, THE NETHERLANDS
Monninger, M.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Aggensteiner, P.-M.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Siehl, S.; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, GERMANY
Floris, D.; Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, THE NETHERLANDS
Bokde, A.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Desrivières, S.; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Flor, H.; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Grigis, A.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Heinz, A.; Department of Psychiatry and Psychotherapy CCM, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Martinot, J.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 ‘Developmental Trajectories & Psychiatry’; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, FRANCE
Paillère Martinot, M.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 ‘Developmental Trajectories & Psychiatry’; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, FRANCE
Papadopoulos Orfanos, D.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Paus, T.; Departments of Psychiatry and Neuroscience and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, Heidelberg University, Heidelberg, GERMANY
Fröhner, J.; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, GERMANY; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Smolka, M.; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, GERMANY; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Vaidya, N.; PONS-Centre, Department of Psychiatry and Clinical Neuroscience, CCM, Charite University Medicine, Berlin, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy CCM, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, G.; PONS-Centre, Department of Psychiatry and Clinical Neuroscience, CCM, Charite University Medicine, Berlin, GERMANY
Meyer-Lindenberg, A.; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Brandeis, D.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Buitelaar, J.; Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, THE NETHERLANDS
Nees, F.; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, GERMANY; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Beckmann, Ch.; Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, THE NETHERLANDS
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Marquand, A.; Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, THE NETHERLANDS
IMAGEN Consortium,
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| Quelle/Jahr | Nature Neuroscience: 26 (2023), 1603 - 1612 |
| ISSN | 1097-6256 (print) ; 1546-1726 (online) |
| DOI | |
| URL | |
| Verlag | New York, NY [u.a.]: Nature Publishing Group |
| Zusammenfassung | Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, the long-term effects of adversity on brain structure and the association of individual neurobiological heterogeneity with behavior have yet to be elucidated. Here we estimated normative models of structural brain development based on a lifespan adversity profile in a longitudinal at-risk cohort aged 25 years (n = 169). This revealed widespread morphometric changes in the brain, with partially adversity-specific features. This pattern was replicated at the age of 33 years (n = 114) and in an independent sample at 22 years (n = 115). At the individual level, greater volume contractions relative to the model were predictive of future anxiety. We show a stable neurobiological signature of adversity that persists into adulthood and emphasize the importance of considering individual-level rather than group-level predictions to explain emerging psychopathology. |
| Kostenfreier Zugang | Open Access Hybrid |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Holz, N., Zabihi, M., Kia, S., Monninger, M., Aggensteiner, P.-M., Siehl, S., Floris, D., Bokde, A., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Brühl, R., Martinot, J.-L., Paillère Martinot, M.-L., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Fröhner, J., Smolka, M., Vaidya, N., Walter, H., Whelan, R., Schumann, G., Meyer-Lindenberg, A., Brandeis, D., Buitelaar, J., Nees, F., Beckmann, C., Banaschewski, T., Marquand, A., & IMAGEN Consortium. (2023). A stable and replicable neural signature of lifespan adversity in the adult brain. Nature Neuroscience, 26, 1603–1612. https://doi.org/10.1038/s41593-023-01410-8