| Zugriffsnummer | 49893 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Psychotic like experiences in healthy adolescents are underpinned by lower fronto-temporal cortical gyrification: a study from the IMAGEN Consortium |
| Autor(in); Institution |
Maitra, R.; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Horne, Ch.M.; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
O'Daly, O.; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Papanastasiou, V.; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Therapeutic Area CNS, Boehringer Ingelheim International GmbH, Inghelheim, GERMANY
Gaser, Ch.; Departments of Neurology, Jena University Hospital, Jena, GERMANY; Departments of Psychiatry and Psychotherapy, Jena University Hospital, Jena, GERMANY
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Barker, G.; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UK
Bokde, A.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Desrivières, S.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King’s College London, UK
Flor, H.; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Grigis, A.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Heinz, A.; Department of Psychiatry and Psychotherapy CCM, Charité Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Martinot, J.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 “Trajectoires développementales en psychiatrie”; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, FRANCE
Paillère Martinot, M.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 “Trajectoires développementales en psychiatrie”; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, FRANCE
Artiges, E.; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 “Trajectoires développementales en psychiatrie”; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, FRANCE
Nees, F.; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Papadopoulous Orfanos, D.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Lemaitre, H.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Paus, T.; Departments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hospitalier Universitaire Sainte- Justine, University of Montreal, Montreal, Quebec, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Hohmann, S.; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Millenet, S.; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Fröhner, J.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Robinson, L.; Department of Psychological Medicine, Section for Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Smolka, M.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy CCM, Charité Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Winterer, J.; Department of Psychiatry and Psychotherapy CCM, Charité Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Quinlan, E.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King’s College London, UK
Ing, A.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King’s College London, UK
Schumann, G.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King’s College London, UK
Shergill, S.; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UK
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| Quelle/Jahr | Schizophrenia Bulletin: 49 (2023), 2, 309 - 318 |
| ISSN | 0586-7614 (print) ; 1745-1701 (online) |
| DOI | |
| Verlag | Oxford: Oxford Univ. Pr. |
| Freie Schlagworte | IMAGEN; MRI ; adolescence ; cortical gyrification ; psychosis ; psychotic like experiences |
| Zusammenfassung | Background and hypothesis: Psychotic Like Experiences (PLEs) are widely prevalent in children and adolescents and increase the risk of developing psychosis. Cortical gyrification characterizes brain development from in utero till about the first 2 years of life and can be measured in later years as static gyrification changes demonstrating neurodevelopment and dynamic gyrification changes reflecting brain maturation during adolescence. We hypothesized that PLEs would be associated with static cortical gyrification changes reflecting a neurodevelopmental abnormality. Study design: We studied 1252 adolescents recruited in the IMAGEN consortium. We used a longitudinal study design, with Magnetic Resonance Imaging measurements at age 14 years and age 19 years; measurement of PLEs using the Community Assessment of Psychic Experiences (CAPE) questionnaire at age 19 years; and clinical diagnoses at age 23 years. Study results: Our results show static gyrification changes in adolescents with elevated PLEs on 3 items of the CAPE-voice hearing, unusual experiences of receiving messages, and persecutory ideas-with lower cortical gyrification in fronto-temporal regions in the left hemisphere. This group also demonstrated dynamic gyrification changes with higher cortical gyrification in right parietal cortex in late adolescence; a finding that we replicated in an independent sample of patients with first-episode psychosis. Adolescents with high PLEs were also 5.6 times more likely to transition to psychosis in adulthood by age 23 years. Conclusions: This is the largest study in adolescents that demonstrates fronto-temporal abnormality of cortical gyrification as a potential biomarker for vulnerability to PLEs and transition to psychosis. |
| Kostenfreier Zugang | Open Access Hybrid |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Maitra, R., Horne, C., O'Daly, O., Papanastasiou, V., Gaser, C., Banaschewski, T., Barker, G., Bokde, A., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Brühl, R., Martinot, J.-L., Paillère Martinot, M.-L., Artiges, E., Nees, F., Papadopoulous Orfanos, D., Lemaitre, H., Paus, T., Poustka, L., Hohmann, S., Millenet, S., Fröhner, J., Robinson, L., Smolka, M., Walter, H., Winterer, J., Whelan, R., Quinlan, E., Ing, A., Schumann, G., & Shergill, S. (2023). Psychotic like experiences in healthy adolescents are underpinned by lower fronto-temporal cortical gyrification: a study from the IMAGEN Consortium. Schizophrenia Bulletin, 49(2), 309–318. https://doi.org/10.1093/schbul/sbac132