Arc controls alcohol cue relapse by a central amygdala mechanism

Pagano, R.; Salamian, A.; Zielinski, J.; Beroun, A.; Nalberczak-Skóra, M.; Skonieczna, E.; Caly, A.; Tay, N.; Banaschewski, T.; Desrivières, S.; Grigis, A.; Garavan, H.; Heinz, A.; Brühl, Rüdiger; Martinot, J.-L.; Paillère Martinot, M.-L.; Artiges, E.; Nees, F.; Papadopoulos Orfanos, D.; Poustka, L.; Hohmann, S.; Fröhner, J.; Smolka, M.; Vaidya, N.; Walter, H.; Whelan, R.; Kalita, K.; Bito, H.; Müller, Ch.; Schumann, G.; Okuno, H.; Radwanska, K.

doi:https://doi.org/10.1038/s41380-022-01849-4

Zugriffsnummer	49883
Dokumenttyp	Zeitschriftenartikel
Peer Review	mit Peer Review
Sprache	Englisch
Titel	Arc controls alcohol cue relapse by a central amygdala mechanism
Autor(in); Institution	Pagano, R.; Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, POLAND Salamian, A.; Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, POLAND Zielinski, J.; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK Beroun, A.; Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, POLAND Nalberczak-Skóra, M.; Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, POLAND Skonieczna, E.; Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, POLAND Caly, A.; Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, POLAND Tay, N.; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY Desrivières, S.; SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK Grigis, A.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA Heinz, A.; Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, GERMANY Brühl, Rüdiger; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin Martinot, J.-L.; Université Paris-Saclay, Institut National de la Santé et de la Recherche Médicale, INSERM U1299 “Trajectoires développementales Psychiatrie”, Ecole Normale Supérieure Paris-Saclay, CNRS UMR 9010, Centre Borelli, Gif-sur-Yvette, FRANCE Paillère Martinot, M.-L.; Université Paris-Saclay, Institut National de la Santé et de la Recherche Médicale, INSERM U1299 “Trajectoires développementales Psychiatrie”, Ecole Normale Supérieure Paris-Saclay, CNRS UMR 9010, Centre Borelli, Gif-sur-Yvette, FRANCE Artiges, E.; Université Paris-Saclay, Institut National de la Santé et de la Recherche Médicale, INSERM U1299 “Trajectoires développementales Psychiatrie”, Ecole Normale Supérieure Paris-Saclay, CNRS UMR 9010, Centre Borelli, Gif-sur-Yvette, FRANCE Nees, F.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY Papadopoulos Orfanos, D.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY Hohmann, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY Fröhner, J.; Department of Psychiatry, Technische Universität Dresden, Dresden, GERMANY Smolka, M.; Department of Psychiatry, Technische Universität Dresden, Dresden, GERMANY Vaidya, N.; SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK Walter, H.; Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, GERMANY Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND Kalita, K.; Laboratory of Neurobiology, BRAINCITY, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, POLAND Bito, H.; Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, JAPAN Müller, Ch.; Section of Addiction Medicine, Department of Psychiatry and Psychotherapy, University Clinic, Friedrich- Alexander-University of Erlangen-Nuremberg, Erlangen, GERMANY Schumann, G.; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, GERMANY Okuno, H.; Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, JAPAN Radwanska, K.; Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, POLAND
Quelle/Jahr	Molecular Psychiatry: 28 (2023), 733 - 745
ISSN	1359-4184 (print) ; 1476-5578 (online)
DOI	https://doi.org/10.1038/s41380-022-01849-4
Verlag	London: Nature Publ.
Zusammenfassung	Alcohol use disorder (AUD) is a chronic and fatal disease. The main impediment of the AUD therapy is a high probability of relapse to alcohol abuse even after prolonged abstinence. The molecular mechanisms of cue-induced relapse are not well established, despite the fact that they may offer new targets for the treatment of AUD. Using a comprehensive animal model of AUD, virallymediated and amygdala-targeted genetic manipulations by CRISPR/Cas9 technology and ex vivo electrophysiology, we identify a mechanism that selectively controls cue-induced alcohol relapse and AUD symptom severity. This mechanism is based on activityregulated cytoskeleton-associated protein (Arc)/ARG3.1-dependent plasticity of the amygdala synapses. In humans, we identified single nucleotide polymorphisms in the ARC gene and their methylation predicting not only amygdala size, but also frequency of alcohol use, even at the onset of regular consumption. Targeting Arc during alcohol cue exposure may thus be a selective new mechanism for relapse prevention.

Relation

https://doi.org/10.1038/s41380-022-01895-y – (Correction)

Themenbereich der Metrologie

Metrologie in der Medizin

Zitierung

Pagano, R., Salamian, A., Zielinski, J., Beroun, A., Nalberczak-Skóra, M., Skonieczna, E., Caly, A., Tay, N., Banaschewski, T., Desrivières, S., Grigis, A., Garavan, H., Heinz, A., Brühl, R., Martinot, J.-L., Paillère Martinot, M.-L., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Poustka, L., Hohmann, S., Fröhner, J., Smolka, M., Vaidya, N., Walter, H., Whelan, R., Kalita, K., Bito, H., Müller, C., Schumann, G., Okuno, H., & Radwanska, K. (2023). Arc controls alcohol cue relapse by a central amygdala mechanism. Molecular Psychiatry, 28, 733–745. https://doi.org/10.1038/s41380-022-01849-4

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