| Zugriffsnummer | 49882 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | A biologically informed polygenic score of neuronal plasticity moderates the association between cognitive aptitudes and cortical thickness in adolescents |
| Autor(in); Institution |
Navarri, X.; Departments of Psychiatry and Neuroscience, Université de Montreal, Montreal, CANADA; CHU Sainte-Justine Research Centre, Montreal, CANADA
Vosberg, D.; Departments of Psychiatry and Neuroscience, Université de Montreal, Montreal, CANADA; CHU Sainte-Justine Research Centre, Montreal, CANADA
Shin, J.; Hospital for Sick Children, University of Toronto, Toronto, CANADA
Richter, L.; Department of Health Sciences, Université du Québec à Chicoutimi, Chicoutimi, CANADA
Leonhard, G.; Montreal Neurological Institute, McGill University, Montreal, CANADA
Pike, B.; Departments of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, CANADA
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, A.; Discipline of Psychiatry, School of Medicine, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Desrivières, S.; SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK
Flor, H.; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, GERMANY; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Grigis, A.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Gowland, P.; Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Heinz, A.; Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, GERMANY
Martinot, J.-L.; Université Paris-Saclay, Institut National de la Santé et de la Recherche Médicale, INSERM U1299 “Trajectoires développementales Psychiatrie”, Ecole Normale Supérieure Paris-Saclay, CNRS UMR 9010, Centre Borelli, Gif-sur-Yvette, FRANCE
Paillère Martinot, M.-L.; Institut National de la Sante et de la Recherche Medicale, INSERM U A10 "Trajectoires d'eveloppementales & psychiatrie", University Paris-Saclay, Ecole Normale Superieure Paris-Saclay, CNRS; Centre Borelli, Gif-sur-Yvette, FRANCE
Artiges, E.; Institut National de la Sante et de la Recherche M'edicale, INSERM U A10 "Trajectoires d'eveloppementales en psychiatrie"; Universit'e Paris-Saclay, Ecole Normale superieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, FRANCE
Nees, F.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Papadopoulos Orfanos, D.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Hohmann, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Fröhner, J.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Smolka, M.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Vaidya, N.; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charite Universitätsmedizin Berlin, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, GERMANY
Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College Dublin, IRELAND
Schumann, G.; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charite Universitätsmedizin Berlin, GERMANY
Pausova, Z.; Departments of Physiology and Nutritional Sciences, Hospital for Sick Children, University of Toronto, Peter Gilgan Centre for Research and Learning, Toronto, CANADA
Paus, T.; Departments of Psychiatry and Neuroscience, Université de Montreal, Montreal, CANADA
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| Quelle/Jahr | Developmental Cognitive Neuroscience: 60 (2023), 1 - 11 |
| Artikelnummer | 101232 |
| ISSN | 1878-9293 (print) ; 1878-9307 (online) |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Freie Schlagworte | Adolescence ; Cognition ; Cortical Thickness ; Fluid intelligence ; Genetics |
| Zusammenfassung | Although many studies of the adolescent brain identified positive associations between cognitive abilities and cortical thickness, little is known about mechanisms underlying such brain-behavior relationships. With experience-induced plasticity playing an important role in shaping the cerebral cortex throughout life, it is likely that some of the inter-individual variations in cortical thickness could be explained by genetic variations in relevant molecular processes, as indexed by a polygenic score of neuronal plasticity (PGS-NP). Here, we studied associations between PGS-NP, cognitive abilities, and thickness of the cerebral cortex, estimated from magnetic resonance images, in the Saguenay Youth Study (SYS, 533 females, 496 males: age=15.0 ± 1.8 years of age; cross-sectional), and the IMAGEN Study (566 females, 556 males; between 14 and 19 years; longitudinal). Using Gene Ontology, we first identified 199 genes implicated in neuronal plasticity, which mapped to 155,600 single nucleotide polymorphisms (SNPs). Second, we estimated their effect sizes from an educational attainment meta-GWAS to build a PGS-NP. Third, we examined a possible moderating role of PGS-NP in the relationship between performance intelligence quotient (PIQ), and its subtests, and the thickness of 34 cortical regions. In SYS, we observed a significant interaction between PGS-NP and object assembly vis-à-vis thickness in male adolescents (p = 0.026). A median-split analysis showed that, in males with a 'high' PGS-NP, stronger associations between object assembly and thickness were found in regions with larger age-related changes in thickness (r = 0.55, p = 0.00075). Although the interaction between PIQ and PGS-NP was non-significant (p = 0.064), we performed a similar median-split analysis. Again, in the high PGS-NP males, positive associations between PIQ and thickness were observed in regions with larger age-related changes in thickness (r = 0.40, p = 0.018). In the IMAGEN cohort, we did not replicate the first set of results (interaction between PGS-NP and cognitive abilities via-a-vis cortical thickness) while we did observe the same relationship between the brain-behaviour relationship and (longitudinal) changes in cortical thickness (Matrix reasoning: r = 0.63, p = 6.5e-05). No statistically significant results were observed in female adolescents in either cohort. Overall, these cross-sectional and longitudinal results suggest that molecular mechanisms involved in neuronal plasticity may contribute to inter-individual variations of cortical thickness related to cognitive abilities during adolescence in a sex-specific manner. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Navarri, X., Vosberg, D., Shin, J., Richter, L., Leonhard, G., Pike, B., Banaschewski, T., Bokde, A., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Brühl, R., Martinot, J.-L., Paillère Martinot, M.-L., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Poustka, L., Hohmann, S., Fröhner, J., Smolka, M., Vaidya, N., Walter, H., Whelan, R., Schumann, G., Pausova, Z., & Paus, T. (2023). A biologically informed polygenic score of neuronal plasticity moderates the association between cognitive aptitudes and cortical thickness in adolescents. Developmental Cognitive Neuroscience, 60, 1–11. https://doi.org/10.1016/j.dcn.2023.101232