| Zugriffsnummer | 49869 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Conduct problems are associated with accelerated thinning of emotion-related cortical regions in a community-based sample of adolescents |
| Autor(in); Institution |
Albaugh, M.; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA
Hudziak, J.; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA
Spechler, P.; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA
Chaarani, B.; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA
Lepage, C.; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, CANADA
Jeon, S.; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, CANADA
Rioux, P.; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, CANADA
Evans, A.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Banaschewski, Tobias; Heidelberg University, Mannheim, GERMANY
Barker, Gareth J.; Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UK
Bokde, Arun L. W.; Trinity College Dublin, IRELAND
Desrivières, Sylvane; nstitute of Psychiatry, Psychology and Neuroscience, King’s College London, UK
Bromberg, Uli; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Flor, Herta; Heidelberg University, Mannheim, GERMANY
Gowland, Penny A.; University of Nottingham, University Park, UK
Heinz, Andreas; Charité - Universitätsmedizin Berlin, GERMANY
Martinot, Jean-Luc; Institut National de la Santé et de la Recherche Médicale (INSERM) and the Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Paillère Martinot, Marie-Laure; Institut National de la Santé et de la Recherche Médicale (INSERM) and the Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Nees, Frauke; Heidelberg University, Mannheim, GERMANY
Papadopoulos Orfanos, Dimitri; Université Paris-Saclay, FRANCE
Paus, Tomáš; Centre Hospitalier Universitaire Sainte -Justine, University of Montreal, Quebec, CANADA
Poustka, Luise; University Medical Centre Göttingen, Göttingen, GERMANY
Fröhner, Juliane H.; Technische Universität Dresden, GERMANY
Smolka, Michael N.; Technische Universität Dresden, GERMANY
Walter, Henrik; Charité - Universitätsmedizin Berlin, GERMANY
Whelan, Robert; Trinity College Dublin, IRELAND
Schumann, Gunter; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, CHINA
Potter, A.; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA
Garvan, Hugh; Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA
IMAGEN Consortium,
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| Quelle/Jahr | Psychiatry Research: 330 (2023), 1 - 7 |
| Artikelnummer | 111614 |
| ISSN | 0165-1781 (print) ; 1872-7123 (online) |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Freie Schlagworte | Brain development ; Conduct problems ; Cortical thickness ; Externalizing |
| Zusammenfassung | Few studies have examined the association between conduct problems and cerebral cortical development. Herein, we characterize the association between age-related brain change and conduct problems in a large longitudinal, community-based sample of adolescents. 1,039 participants from the IMAGEN study possessed psychopathology and surface-based morphometric data at study baseline (M = 14.42 years, SD = 0.40; 559 females) and 5-year follow-up. Self-reports of conduct problems were obtained using the Strengths and Difficulties Questionnaire (SDQ). Vertex-level linear mixed effects models were implemented using the Matlab toolbox, SurfStat. To investigate the extent to which cortical thickness maturation was qualified by dimensional measures of conduct problems, we tested for an interaction between age and SDQ Conduct Problems (CP) score. There was no main effect of CP score on cortical thickness; however, a significant "Age by CP" interaction was revealed in bilateral insulae, left inferior frontal gyrus, left rostral anterior cingulate, left posterior cingulate, and bilateral inferior parietal cortices. Across regions, follow-up analysis revealed higher levels of CP were associated with accelerated age-related thinning. Findings were not meaningfully altered when controlling for alcohol use, co-occurring psychopathology, and socioeconomic status. Results may help to further elucidate neurodevelopmental patterns linking adolescent conduct problems with adverse adult outcomes≪ |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Albaugh, M., Hudziak, J., Spechler, P., Chaarani, B., Lepage, C., Jeon, S., Rioux, P., Evans, A., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Desrivières, S., Bromberg, U., Flor, H., Gowland, P. A., Heinz, A., Ittermann, B., Martinot, J.-L., Paillère Martinot, M.-L., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Fröhner, J. H., Smolka, M. N., Walter, H., Whelan, R., Schumann, G., Potter, A., Garvan, H., & IMAGEN Consortium. (2023). Conduct problems are associated with accelerated thinning of emotion-related cortical regions in a community-based sample of adolescents. Psychiatry Research, 330, 1–7. https://doi.org/10.1016/j.pscychresns.2023.111614