| Zugriffsnummer | 49484 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | FLASHlab@PITZ: New R&D Platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ |
| Autor(in); Institution |
Stephan, Frank; Deutsches Elektronen-Synchrotron DESY, Zeuthen, GERMANY
Gross, Matthias; Deutsches Elektronen-Synchrotron DESY, Zeuthen, GERMANY
Grebinyk, Anna; Deutsches Elektronen-Synchrotron DESY, Zeuthen, GERMANY
Aboulbanine, Zakaria; Deutsches Elektronen-Synchrotron DESY, Zeuthen, GERMANY; On Leave from University Mohammed V, Rabat, MOROCCO
Amirkhanyan, Zohrab; Deutsches Elektronen-Synchrotron DESY, Zeuthen, GERMANY; On Leave from CANDLE Synchrotron Research Institute, Yerevan, ARMENIA
Budach, Volker; Department of Radiotherapy, Charité Berlin, CCM/CVK, Berlin, GERMANY
Ehrhardt, Vincent Henrique; University Medical Center Hamburg-Eppendorf, Hamburg, GERMANY
Faus-Golfe, Angeles; Laboratoire de Physique des 2 Infinies, Irene Joliot-Curie Laboratory IJCLab, CNRS/IN2P3, Universite Paris-Saclay, Orsay, FRANCE
Frohme, Marcus; Technical University of Applied Sciences Wildau, Wildau, GERMANY
Germond, Jean-Francois; CHUV, Institut de Radiophysique, Lausanne, SWITZERLAND
Good, James David; Deutsches Elektronen-Synchrotron DESY, Zeuthen, GERMANY
Grüner, Florian; Universität Hamburg and Center for Free-Electron Laser Science, Hamburg, GERMANY
Kaul, David; Department of Radiotherapy, Charité Berlin, CCM/CVK, Berlin, GERMANY
Krasilnikov, Mikhail; Deutsches Elektronen-Synchrotron DESY, Zeuthen, GERMANY
Leavitt, Ron; CHUV, Service de Radio-Oncologie, Lausanne, SWITZERLAND
Leemans, Wim; Deutsches Elektronen-Synchrotron DESY, Hamburg, GERMANY
Li, Xiangkun; Deutsches Elektronen-Synchrotron DESY, Zeuthen, GERMANY
Loisch, Gregor; Deutsches Elektronen-Synchrotron DESY, Hamburg, GERMANY
Müller, Frieder; Deutsches Elektronen-Synchrotron DESY, Zeuthen, GERMANY
Müller, Georg; Karlsruhe Institute of Technology (KIT), Institute for Pulsed Power and Microwave Technology (IHM), Eggenstein-Leopoldshafen, GERMANY
Obier, Frank; Deutsches Elektronen-Synchrotron DESY, Hamburg, GERMANY
Oppelt, Anne; Deutsches Elektronen-Synchrotron DESY, Zeuthen, GERMANY
Philipp, Sebastian; Deutsches Elektronen-Synchrotron DESY, Zeuthen, GERMANY
Qian, Houjun; Deutsches Elektronen-Synchrotron DESY, Zeuthen, GERMANY
Reindl, Judith; Universität der Bundeswehr München, Neubiberg, GERMANY
Riemer, Felix; Deutsches Elektronen-Synchrotron DESY, Zeuthen, GERMANY
Sack, Martin; Karlsruhe Institute of Technology (KIT), Institute for Pulsed Power and Microwave Technology (IHM), Eggenstein-Leopoldshafen, GERMANY
Schmitz, Michael; Deutsches Elektronen-Synchrotron DESY, Hamburg, GERMANY
Schnautz, Tobias; Deutsches Elektronen-Synchrotron DESY, Hamburg, GERMANY
Staufer, Theresa; Universität Hamburg and Center for Free-Electron Laser Science, Hamburg, GERMANY
Stegmann, Christian; Deutsches Elektronen-Synchrotron DESY, Zeuthen, GERMANY
Tsakanova, Gohar; Institute of Molecular Biology NAS RA, Yerevan, ARMENIA; CANDLE Synchrotron Research Institute, Yerevan, ARMENIA
Vozenin, Marie-Catherine; CHUV, Service de Radio-Oncologie, Lausanne, SWITZERLAND
Weise, Hans; Deutsches Elektronen-Synchrotron DESY, Hamburg, GERMANY
Worm, Steven; Deutsches Elektronen-Synchrotron DESY, Zeuthen, GERMANY
Zips, Daniel; Department of Radiotherapy, Charité Berlin, CCM/CVK, Berlin, GERMANY
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| Quelle/Jahr | Physica Medica: 104 (2022), 174 - 187 |
| ISSN | 1120-1797 (print) ; 1724-191X (online) |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Freie Schlagworte | FLASH and VHEE radiation therapy ; Ultra-high dose rate ; Flexible electron accelerator ; Online image guiding ; Uniquely wide parameter range |
| Zusammenfassung | At the Photo Injector Test facility at DESY in Zeuthen (PITZ), an R&D platform for electron FLASH and very high energy electron radiation therapy and radiation biology is being prepared (FLASHlab@PITZ). The beam parameters available at PITZ are worldwide unique. They are based on experiences from 20 + years of developing high brightness beam sources and an ultra-intensive THz light source demonstrator for ps scale electron bunches with up to 5 nC bunch charge at MHz repetition rate in bunch trains of up to 1 ms length, currently 22 MeV (upgrade to 250 MeV planned). Individual bunches can provide peak dose rates up to 1014 Gy/s, and 10 Gy can be delivered within picoseconds. Upon demand, each bunch of the bunch train can be guided to a different transverse location, so that either a "painting" with micro beams (comparable to pencil beam scanning in proton therapy) or a cumulative increase of absorbed dose, using a wide beam distribution, can be realized at the tumor. Full tumor treatment can hence be completed within 1 ms, mitigating organ movement issues. With extremely flexible beam manipulation capabilities, FLASHlab@PITZ will cover the current parameter range of successfully demonstrated FLASH effects and extend the parameter range towards yet unexploited short treatment times and high dose rates. A summary of the plans for FLASHlab@PITZ and the status of its realization will be presented. |
Zitierung
Stephan, F., Gross, M., Grebinyk, A., Aboulbanine, Z., Amirkhanyan, Z., Budach, V., Ehrhardt, V. H., Faus-Golfe, A., Frohme, M., Germond, J.-F., Good, J. D., Grüner, F., Kaul, D., Krasilnikov, M., Leavitt, R., Leemans, W., Li, X., Loisch, G., Müller, F., Müller, G., Obier, F., Oppelt, A., Philipp, S., Qian, H., Reindl, J., Riemer, F., Sack, M., Schmitz, M., Schnautz, T., Schüller, A., Staufer, T., Stegmann, C., Tsakanova, G., Vozenin, M.-C., Weise, H., Worm, S., & Zips, D. (2022). FLASHlab@PITZ: New R&D Platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ. Physica Medica, 104, 174–187. https://doi.org/10.1016/j.ejmp.2022.10.026