Repair kinetics of DSB-foci induced by proton and α-particle microbeams of different energies

Belchior, Ana; Canhoto, Joan F.; Langner, Frank; Giesen, Ulrich; Schulte, Reinhard; Rabus, Hans

doi:https://doi.org/10.3390/life12122040

Zugriffsnummer	49336
Dokumenttyp	Zeitschriftenartikel
Peer Review	mit Peer Review
Sprache	Englisch
Titel	Repair kinetics of DSB-foci induced by proton and α-particle microbeams of different energies
Autor(in); Institution	Belchior, Ana; Instituto Superior Técnico, Universidade de Lisboa, Bobadela, PORTUGAL Canhoto, Joan F.; Instituto Superior Técnico, Universidade de Lisboa, Bobadela, PORTUGAL; Instituto Superior Técnico-IST, Universidade de Lisboa, Lisboa, PORTUGAL Langner, Frank; 6.4, Neutronenstrahlung, PTB-Braunschweig Giesen, Ulrich; 6.4, Neutronenstrahlung, PTB-Braunschweig Schulte, Reinhard; Loma Linda University, Loma Linda, USA Rabus, Hans; 8, Medizinphysik und metrologische Informationstechnik, PTB-Berlin
Quelle/Jahr	Special Issue Ionizing Radiation of High LET and DNA Damage Responses. Life: 12 (2022), 12, 1 - 15
Artikelnummer	2040
Availability	[online only]
ISSN	2075-1729 (online)
DOI	https://doi.org/10.3390/life12122040
Verlag	Basel: MDPI
Freie Schlagworte	radiation-induced foci ; track structure ; DNA damage repair
Zusammenfassung	In this work, the induction and repair of radiation-induced 53BP1 foci were studied in human umbilical vein endothelial cells irradiated at the PTB microbeam with protons and α-particles of different energies. The data were analyzed in terms of the mean number of 53BP1 foci induced by the different ion beams. The number of 53BP1 foci found at different times post-irradiation suggests that the disappearance of foci follows first order kinetics. The mean number of initially produced foci shows the expected increase with LET. The most interesting finding of this work is that the absolute number of persistent foci increases with LET but not their fraction. Furthermore, protons seem to produce more persistent foci as compared to α-particles of even higher LET. This may be seen as experimental evidence that protons may be more effective in producing severe DNA lesions, as was already shown in other work, and that LET may not be the best suited parameter to characterize radiation quality.

Kostenfreier Zugang	Open Access Gold
Rechteinformation	CC BY-NC 4.0 ; Creative Commons Attribution NonCommercial 4.0 License

Themenbereich der Metrologie	Ionisierende Strahlung
Forschungsprojekt	SIB06: BioQuaRT: Biologically weighted quantities in radiotherapy
Förderinformationen (1)	Förderername: European Commission (EC) Förderer ID: 0000 0001 2242 8989 Förderer ID Typ: ISNI Förderprogramm: EMPIR 2011 SI Broader Scope Titel der Förderung: SIB06: BioQuaRT: Biologically weighted quantities in radiotherapy Förderungsnummer: SIB06

Zitierung

Belchior, A., Canhoto, J. F., Langner, F., Giesen, U., Schulte, R., & Rabus, H. (2022). Repair kinetics of DSB-foci induced by proton and α-particle microbeams of different energies. Life, 12(12), 1–15. https://doi.org/10.3390/life12122040

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