| Zugriffsnummer | 48801 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Spontaneous polarization and cell guidance on asymmetric nanotopography |
| Autor(in); Institution |
Winkler, Benjamin; 8.4, Mathematische Modellierung und Datenanalyse, PTB-Berlin
Herr, Corey; Department of Physics, University of Maryland, College Park, Md., USA
Ziebert, Falko; Institute for Theoretical Physics, Heidelberg University, Heidelberg, GERMANY
Aranson, Igor S.; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA
Fourkas, John T.; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA; Institute for Physical Science and Technology, University of Maryland, College Park, MD, USA
Losert, Wolfgang; Department of Physics, University of Maryland, College Park, MD, USA; Institute for Physical Science and Technology, University of Maryland, College Park, MD, USA
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| Quelle/Jahr | Communications Physics:(2022), 5 |
| Artikelnummer | 114 |
| Availability | [online only] |
| ISSN | 2399-3650 (ONLINE) |
| DOI | |
| Verlag | London: Springer Nature |
| Freie Schlagworte | Spontaneous polarization ; asymmetric nanotopography |
| Zusammenfassung | Asymmetric nanotopography with sub-cellular dimensions has recently demonstrated the ability to provide a unidirectional bias in cell migration. The details of this guidance depend on the type of cell studied and the design of the nanotopography. This behavior is not yet well understood, so there is a need for a predictive description of cell migration on such nanotopography that captures both the initiation of migration, and the way cell migration evolves. Here, we employ a three-dimensional, physics-based model to study cell guidance on asymmetric nanosawteeth. In agreement with experimental data, our model predicts that asymmetric sawteeth lead to spontaneous motion. Our model demonstrates that the nanosawteeth induce a unidirectional bias in guidance direction that is dependent upon actin polymerization rate and sawtooth dimensions. Motivated by this model, an analysis of previously reported experimental data indicates that the degree of guidance by asymmetric nanosawteeth increases with the cell velocity. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |