| Zugriffsnummer | 48741 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning |
| Autor(in); Institution |
Owens, M.; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, VT, USA
Albaugh, M.; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, VT, USA
Allgaier, N.; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, VT, USA
Yuan, D.; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, VT, USA
Robert, G.; Psychiatry Department, University of Rennes, Rennes, FRANCE
Cupertino, R.; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, VT, USA
Spechler, P.; Laureate Institute for Brain Research, Tulsa, OK, USA
Juliano, A.; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, VT, USA
Hahn, S.; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, VT, USA
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, A.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Desrivières, S.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King’s College London, London, UK
Flor, H.; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, GERMANY; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Grigis, A.; NeuroSpin, CEA, Université Paris-Saclay, F-91191, Gif-sur-Yvette, FRANCE
Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Heinz, A.; Department of Psychiatry and Psychotherapy Campus Charité Mitte, Charité-Universitätsmedizin, corporate member of Freie Universität Berlin & Humboldt-Universität zu Berlin, Berlin, GERMANY
Martinot, J.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM U A10 “Trajectoires développementales en psychiatrie”; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, FRANCE
Paillère Martinot, M.-L.; Institut National de la Santé et de la Recherce Médicale, INSERM U A10 “Trajectoires développementales & psychiatrie”, University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS; Centre Borelli, Gif-sur-Yvette, FRANCE; AP-HP. Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, FRANCE
Artiges, E.; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 “Trajectoires développementales en psychiatrie”; Ecole Normale supérieure Paris-Saclay, Université Paris-Saclay, Université de Paris, Centre Borelli; Gif-sur-Yvette, & Department of Psychiatry, EPS Barthélémy Durand, Etampes, FRANCE
Nees, F.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, GERMANY; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, GERMANY
Papadopoulos Orfanos, D.; NeuroSpin, CEA, Université Paris-Saclay, F-91191, Gif-sur-Yvette, FRANCE
Lemaitre, H.; NeuroSpin, CEA, Université Paris-Saclay, F-91191, Gif-sur-Yvette, FRANCE; Institut des Maladies Neurodégénératives, CNRS UMR 5293, Université de Bordeaux, Centre Broca Nouvelle-Aquitaine, Bordeaux, FRANCE
Paus, T.; Departments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, QC, CANADA; Departments of Psychology, University of Toronto, Toronto, ON, CANADA; Department of Psychiatry, University of Toronto, Toronto, ON, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Millenet, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Fröhner, J. H.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Smolka, M. N.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy Campus Charité Mitte, Charité-Universitätsmedizin, corporate member of Freie Universität Berlin & Humboldt-Universität zu Berlin, Berlin, GERMANY
Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Mackey, S.; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, VT, USA
Schumann, G.; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, GERMANY; Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, CHINA
Garavan, H.; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, VT, USA
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| Quelle/Jahr | Translational Psychiatry: 12 (2022), 1 - 9 |
| Artikelnummer | 188 |
| Availability | [online only] |
| ISSN | 2158-3188 (ONLINE) |
| DOI | |
| Verlag | London [u.a.]: Nature |
| Zusammenfassung | While there is substantial evidence that cannabis use is associated with differences in human brain development, most of this evidence is correlational in nature. Bayesian causal network (BCN) modeling attempts to identify probable causal relationships in correlational data using conditional probabilities to estimate directional associations between a set of interrelated variables. In this study, we employed BCN modeling in 637 adolescents from the IMAGEN study who were cannabis naïve at age 14 to provide evidence that the accelerated prefrontal cortical thinning found previously in adolescent cannabis users by Albaugh et al. [1] is a result of cannabis use causally affecting neurodevelopment. BCNs incorporated data on cannabis use, prefrontal cortical thickness, and other factors related to both brain development and cannabis use, including demographics, psychopathology, childhood adversity, and other substance use. All BCN algorithms strongly suggested a directional relationship from adolescent cannabis use to accelerated cortical thinning. While BCN modeling alone does not prove a causal relationship, these results are consistent with a body of animal and human research suggesting that adolescent cannabis use adversely affects brain development. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Owens, M., Albaugh, M., Allgaier, N., Yuan, D., Robert, G., Cupertino, R., Spechler, P., Juliano, A., Hahn, S., Banaschewski, T., Bokde, A., Desrivières, S., Flor, H., Grigis, A., Gowland, P., Heinz, A., Brühl, R., Martinot, J.-L., Paillère Martinot, M.-L., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Lemaitre, H., Paus, T., Poustka, L., Millenet, S., Fröhner, J. H., Smolka, M. N., Walter, H., Whelan, R., Mackey, S., Schumann, G., & Garavan, H. (2022). Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning. Translational Psychiatry, 12, 1–9. https://doi.org/10.1038/s41398-022-01956-4