| Zugriffsnummer | 48740 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Structural differences in adolescent brains can predict alcohol misuse |
| Autor(in); Institution |
Prakash Rane, R.; Charité - Universitätsmedizin Berlin (corporate member of Freie Universität at Berlin, Humboldt-Universität at zu Berlin, and Berlin Institute of Health), Department of Psychiatry and Psychotherapy, Bernstein Center for Computational Neuroscience, Berlin, GERMANY
de Man, E.F.; Faculty IV - Electrical Engineering and Computer Science, Technische Universität Berlin, Berlin, GERMANY
Kim, J.; Department of Education and Psychology, Freie Universität Berlin, Berlin, GERMANY
Tschorn, M.; Social and Preventive Medicine, Department of Sports and Health Sciences, Intra-faculty unit "Cognitive Sciences", Faculty of Human Science, and Faculty of Health Sciences Brandenburg, Research Area Services Research and e-Health, University of Potsdam, Potsdam, GERMANY
Görgen, K.; Charité - Universitätsmedizin Berlin (corporate member of Freie Universität at Berlin, Humboldt-Universität at zu Berlin, and Berlin Institute of Health), Department of Psychiatry and Psychotherapy, Bernstein Center for Computational Neuroscience, Berlin, GERMANY
Rapp, M.A.; Social and Preventive Medicine, Department of Sports and Health Sciences, Intra-faculty unit "Cognitive Sciences", Faculty of Human Science, and Faculty of Health Sciences Brandenburg, Research Area Services Research and e-Health, University of Potsdam, Potsdam, GERMANY
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, A.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Desrivieres, S.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology Neuroscience SGDP Centre, King’s College London, London, UK
Flor, H.; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GERMANY
Grigis, A.; NeuroSpin, CEA, Université Paris-Saclay, Paris, FRANCE
Garven, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, USA
Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, UK
Martinot, J.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry”, University Paris Sud, University Paris Descartes, Sorbonne Paris Cité and Maison de Solenn, Paris, FRANCE
Paillère Martinot, M.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry”, University Paris Sud, University Paris Descartes, Sorbonne Paris Cité and Maison de Solenn, Paris, FRANCE; AP-HP Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, FRANCE
Artiges, E.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry”, University Paris Sud, University Paris Descartes, Sorbonne Paris Cité and Psychiatry Department, Orsay Hospital, FRANCE; Psychiatry Department, EPS Barthélémy Durand, Etampes, FRANCE
Nees, F.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GERMANY; PONS Research Group, Dept. of Psychiatry and Psychotherapy, Campus Charite Mitte, Humboldt University, Berlin, GERMANY
Papadopoulos Orfanos, D.; NeuroSpin, CEA, Université Paris-Saclay, Paris, FRANCE
Lemaitre, H.; NeuroSpin, CEA, Université Paris-Saclay, Paris, FRANCE; Institut des Maladies Neurodégénératives, UMR 5293, CNRS, CEA, University of Bordeaux, Bordeaux, FRANCE
Paus, T.; Department of Psychiatry, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, CANADA; Departments of Psychiatry and Psychology, University of Toronto, Toronto, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Fröhner, J.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Robinson, L.; Department of Psychological Medicine, Section for Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Smolka, M. N.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Winterer, J.; Charité - Universitätsmedizin Berlin (corporate member of Freie Universität at Berlin, Humboldt-Universität at zu Berlin, and Berlin Institute of Health), Department of Psychiatry and Psychotherapy, Bernstein Center for Computational Neuroscience, Berlin, GERMANY
Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, G.; PONS Research Group, Dept of Psychiatry and Psychotherapy, Campus Charite Mitte, Humboldt University, Berlin, GERMANY
Walter, H.; Charité - Universitätsmedizin Berlin (corporate member of Freie Universität at Berlin, Humboldt-Universität at zu Berlin, and Berlin Institute of Health), Department of Psychiatry and Psychotherapy, Bernstein Center for Computational Neuroscience, Berlin, GERMANY
Heinz, A.; Charité - Universitätsmedizin Berlin (corporate member of Freie Universität at Berlin, Humboldt-Universität at zu Berlin, and Berlin Institute of Health), Department of Psychiatry and Psychotherapy, Bernstein Center for Computational Neuroscience, Berlin, GERMANY
Ritter, K.; Charité - Universitätsmedizin Berlin (corporate member of Freie Universität at Berlin, Humboldt-Universität at zu Berlin, and Berlin Institute of Health), Department of Psychiatry and Psychotherapy, Bernstein Center for Computational Neuroscience, Berlin, GERMANY
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| Quelle/Jahr | ELife:(2022), 1 - 33 |
| Availability | [online only] |
| ISSN | 2050-084X (ONLINE) |
| DOI | |
| Persistent Identifier | |
| Verlag | Cambridge: ELife Sciences Publ. |
| Zusammenfassung | Alcohol misuse during adolescence (AAM) has been associated with disruptive development of adolescent brains. In this longitudinal machine learning (ML) study, we could predict AAM significantly from brain structure (T1-weighted imaging and DTI) with accuracies of 73 -78% in the IMAGEN dataset (n∼1182). Our results not only show that structural differences in brain can predict AAM, but also suggests that such differences might precede AAM behavior in the data. We predicted 10 phenotypes of AAM at age 22 using brain MRI features at ages 14, 19, and 22. Binge drinking was found to be the most predictable phenotype. The most informative brain features were located in the ventricular CSF, and in white matter tracts of the corpus callosum, internal capsule, and brain stem. In the cortex, they were spread across the occipital, frontal, and temporal lobes and in the cingulate cortex. We also experimented with four different ML models and several confound control techniques. Support Vector Machine (SVM) with rbf kernel and Gradient Boosting consistently performed better than the linear models, linear SVM and Logistic Regression. Our study also demonstrates how the choice of the predicted phenotype, ML model, and confound correction technique are all crucial decisions in an explorative ML study analyzing psychiatric disorders with small effect sizes such as AAM. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Prakash Rane, R., de Man, E., Kim, J., Tschorn, M., Görgen, K., Rapp, M., Banaschewski, T., Bokde, A., Desrivieres, S., Flor, H., Grigis, A., Garven, H., Gowland, P., Brühl, R., Martinot, J.-L., Paillère Martinot, M.-L., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Lemaitre, H., Paus, T., Poustka, L., Fröhner, J., Robinson, L., Smolka, M. N., Winterer, J., Whelan, R., Schumann, G., Walter, H., Heinz, A., & Ritter, K. (2022). Structural differences in adolescent brains can predict alcohol misuse. ELife, 1–33. https://doi.org/10.7554/eLife.77545