Criteria for the design of tissue-mimicking phantoms for the standardization of biophotonic instrumentation
Autor(in); Institution
Hacker, Lina; Department of Physics, University of Cambridge, Cambridge, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK
Pifferi, Antonio; Department of Physics, Politecnico di Milano, Milan, ITALY
Pfefer, Joshua T.; US Food and Drug Administration, Silver Spring, MD, USA
Pogue, Brian W.; Thayer School of Engineering, Dartmouth, Hanover, NH, USA
Bohndiek, Sarah E.; Department of Physics, University of Cambridge, Cambridge, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK
A lack of accepted standards and standardized phantoms suitable for the technical validation of biophotonic instrumentation hinders the reliability and reproducibility of its experimental outputs. In this Perspective, we discuss general criteria for the design of tissue-mimicking biophotonic phantoms, and use these criteria and state-of-the-art developments to critically review the literature on phantom materials and on the fabrication of phantoms. By focusing on representative examples of standardization in diffuse optical imaging and spectroscopy, fluorescence-guided surgery and photoacoustic imaging, we identify unmet needs in the development of phantoms and a set of criteria (leveraging characterization, collaboration, communication and commitment) for the standardization of biophotonic instrumentation.
Themenbereich der Metrologie
Metrologie in der Medizin
Zitierung
Hacker, L., Wabnitz, H., Pifferi, A., Pfefer, J. T., Pogue, B. W., & Bohndiek, S. E. (2022). Criteria for the design of tissue-mimicking phantoms for the standardization of biophotonic instrumentation. Nature Biomedical Engineering, 6(5), 541–558. https://doi.org/10.1038/s41551-022-00890-6
