| Zugriffsnummer | 47550 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Improved spatio‑temporal measurements of visually evoked fields using optically‑pumped magnetometers |
| Autor(in); Institution |
Gialopsou, A.; Department of Physics and Astronomy, University of Sussex, Falmer, Brighton, UK; Clinical Imaging Sciences Centre, University of Sussex, Falmer, Brighton , UK
Abel, C.; Department of Physics and Astronomy, University of Sussex, Falmer, Brighton, UK
James, T. M.; Department of Physics and Astronomy, University of Sussex, Falmer, Brighton, UK
Coussens, T.; Department of Physics and Astronomy, University of Sussex, Falmer, Brighton, UK
Bason, M. G.; Department of Physics and Astronomy, University of Sussex, Falmer, Brighton, UK
Puddy, R.; Department of Physics and Astronomy, University of Sussex, Falmer, Brighton, UK
Lorenzo, F. D.; Clinical Imaging Sciences Centre, University of Sussex, Falmer, Brighton , UK
Rolfs, Katharina; 8.2, Biosignale, PTB-Berlin
Cercignani, M.; Clinical Imaging Sciences Centre, University of Sussex, Falmer, Brighton , UK; Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK
|
| Quelle/Jahr | Scientific Reports: 11 (2021), 11 S. |
| Artikelnummer | 22412 |
| Availability | [online only] |
| ISSN | 2045-2322 (ONLINE) |
| DOI | |
| Verlag | London: Nature Publishing Group |
| Zusammenfassung | Recent developments in performance and practicality of optically-pumped magnetometers (OPMs) have enabled new capabilities in non-invasive brain function mapping through magnetoencephalography. In particular, the lack of cryogenic operating conditions allows for more flexible placement of sensor heads closer to the brain, leading to improved spatial resolution and source localisation capabilities. Through recording visually evoked brain fields (VEFs), we demonstrate that the closer sensor proximity can be exploited to improve temporal resolution. We use OPMs, and superconducting quantum interference devices (SQUIDs) for reference, to measure brain responses to flash and pattern reversal stimuli. We find highly reproducible signals with consistency across multiple participants, stimulus paradigms and sensor modalities. The temporal resolution advantage of OPMs is manifest in a twofold improvement, compared to SQUIDs. The capability for improved spatio-temporal signal tracing is illustrated by simultaneous vector recordings of VEFs in the primary and associative visual cortex, where a time lag on the order of 10–20 ms is consistently found. This paves the way for further spatio-temporal studies of neurophysiological signal tracking in visual stimulus processing, and other brain responses, with potentially far-reaching consequences for time-critical mapping of functionality in healthy and pathological brains. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
| Förderinformationen (1) |
Förderername: Deutsche Forschungsgemeinschaft (DFG)
Förderer ID: 0000 0001 2096 9829 Förderer ID Typ: ISNI Förderungsnummer: DFG KO 5321/3-1 and TR 408/11- 1 |
| Förderinformationen (2) |
Förderername: Engineering and Physical Sciences Research Council (EPSRC)
Förderer ID: 0000 0004 0394 8681 Förderer ID Typ: ISNI Förderprogramm: UK Quantum Technologies Hub for Sensors and Timing Förderungsnummer: EPSRC Grant EP/T001046/1 |
Zitierung
Gialopsou, A., Abel, C., James, T. M., Coussens, T., Bason, M. G., Puddy, R., Lorenzo, F. D., Rolfs, K., Voigt, J., Sander-Thömmes, T., Cercignani, M., & Krüger, P. (2021). Improved spatio‑temporal measurements of visually evoked fields using optically‑pumped magnetometers. Scientific Reports, 11, 11 S. https://doi.org/10.1038/s41598-021-01854-7