| Zugriffsnummer | 47004 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents |
| Autor(in); Institution |
Li, J.; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, CHINA
Liu, B.; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, CHINA
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, A.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Burke Quinlan, E.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK
Desrivières, S.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK
Flor, H.; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Frouin, V.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Heinz, A.; Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, J.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 ‘Neuroimaging & Psychiatry’, University Paris-Saclay, University Paris Descartes - Sorbonne Paris Cité,; and Maison de Solenn, Paris, FRANCE
Artiges, E.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 ‘Neuroimaging & Psychiatry’, University Paris-Saclay, University Paris Descartes - Sorbonne Paris Cité; and Psychiatry Department, Orsay Hospital, Orsay, FRANCE
Nees, F.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Papdopoulos Orfanos, D.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Paus, T.; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, CANADA; Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Hohmann, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Fröhner, J.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Smolka, M.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, G.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK PONS Research Group, Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Berlin, GERMANY; Leibniz Institute for Neurobiology, Magdeburg, GERMANY
Jiang, T.; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, CHINA
IMAGEN Consortium,
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| Quelle/Jahr | Psychological Medicine:(2020), 8 S. |
| Availability | [online first] |
| ISSN | 0033-2917 (PRINT) ; 1469-8978 (ONLINE) |
| DOI | |
| Verlag | Cambridge: Cambridge University Press |
| Freie Schlagworte | cortical volume ; orbitofrontal cortex ; polygenic risk score ; smoking ; tobacco use |
| Zusammenfassung | Background: Tobacco smoking remains one of the leading causes of preventable illness and death and is heritable with complex underpinnings. Converging evidence suggests a contribution of the polygenic risk for smoking to the use of tobacco and other substances. Yet, the underlying brain mechanisms between the genetic risk and tobacco smoking remain poorly understood. Methods: Genomic, neuroimaging, and self-report data were acquired from a large cohort of adolescents from the IMAGEN study (a European multicenter study). Polygenic risk scores (PGRS) for smoking were calculated based on a genome-wide association study meta-analysis conducted by the Tobacco and Genetics Consortium. We examined the interrelationships among the genetic risk for smoking initiation, brain structure, and the number of occasions of tobacco use. Results: A higher smoking PGRS was significantly associated with both an increased number of occasions of tobacco use and smaller cortical volume of the right orbitofrontal cortex (OFC). Furthermore, reduced cortical volume within this cluster correlated with greater tobacco use. A subsequent path analysis suggested that the cortical volume within this cluster partially mediated the association between the genetic risk for smoking and the number of occasions of tobacco use. Conclusions: Our data provide the first evidence for the involvement of the OFC in the relationship between smoking PGRS and tobacco use. Future studies of the molecular mechanisms underlying tobacco smoking should consider the mediation effect of the related neural structure. |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Li, J., Liu, B., Banaschewski, T., Bokde, A., Burke Quinlan, E., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Artiges, E., Nees, F., Papdopoulos Orfanos, D., Paus, T., Poustka, L., Hohmann, S., Fröhner, J., Smolka, M., Walter, H., Whelan, R., Schumann, G., Jiang, T., & IMAGEN Consortium. (2020). Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents. Psychological Medicine, 8 S. https://doi.org/10.1017/s0033291720002962