| Zugriffsnummer | 46983 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Association of cannabis use during adolescence with neurodevelopment |
| Autor(in); Institution |
Albaugh, Matthew; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, USA
Ottino-Gonzalez, Jonatan; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, USA
Sidwell, Amanda; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, USA
Lepage, Claude; McConnell Brain Imaging Centre, McGill University, Montreal, Quebec, CANADA
Juliano, Anthony; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, USA
Owens, Max M.; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, USA
Chaarani, Bader; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, USA
Spechler, Philip; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, USA
Fontaine, Nicholas; Department of Psychiatry, University of Vermont Larner College of Medicine, Burlington, USA
Rioux, Pierre; McConnell Brain Imaging Centre, McGill University, Montreal, Quebec, CANADA
Lewis, Lindsay; McConnell Brain Imaging Centre, McGill University, Montreal, Quebec, CANADA
Jeon, Seun; McConnell Brain Imaging Centre, McGill University, Montreal, Quebec, CANADA
Evans, Alan; McConnell Brain Imaging Centre, McGill University, Montreal, Quebec, CANADA
D'Souza, Deepak; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Radhakrishnan, Rajiv; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, Arun L. W; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Quinlan, Erin Burke; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology, and Neuroscience, Social, Genetic & Developmental Psychiatry Centre, King’s College London, London, UK
Conrod, Patricia; Department of Psychiatry, University of Montreal, Montreal, Quebec, CANADA
Desrivieres, Syvane; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology, and Neuroscience, Social, Genetic & Developmental Psychiatry Centre, King’s College London, London, UK
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
|
| Quelle/Jahr | JAMA Psychiatry: 78 (2021), 9, 1031 - 1040 |
| ISSN | 2168-622X (PRINT) ; 2168-6238 (ONLINE) |
| DOI | |
| URL | |
| Verlag | Chicago, Ill.: AMA |
| Zusammenfassung | IMPORTANCE Animal studies have shown that the adolescent brain is sensitive to disruptions in endocannabinoid signaling, resulting in altered neurodevelopment and lasting behavioral effects. However, few studies have investigated ties between cannabis use and adolescent brain development in humans. OBJECTIVE To examine the degree to which magnetic resonance (MR) imaging–assessed cerebral cortical thickness development is associated with cannabis use in a longitudinal sample of adolescents. DESIGN, SETTING, AND PARTICIPANTS Datawere obtained from the community-based IMAGEN cohort study, conducted across 8 European sites. Baseline data used in the present study were acquired from March 1, 2008, to December 31, 2011, and follow-up data were acquired from January 1, 2013, to December 31, 2016. A total of 799 IMAGEN participants were identified who reported being cannabis naive at study baseline and had behavioral and neuroimaging data available at baseline and 5-year follow-up. Statistical analysis was performed from October 1, 2019, to August 31, 2020. MAIN OUTCOMES AND MEASURES Cannabis usewas assessed at baseline and 5-year follow-up with the European School Survey Project on Alcohol and Other Drugs. Anatomical MR images were acquired with a 3-dimensional T1-weighted magnetization prepared gradient echo sequence. Quality-controlled nativeMR images were processed through the CIVET pipeline, version 2.1.0. RESULTS The study evaluated 1598 MR images from 799 participants (450 female participants [56.3%]; mean [SD] age, 14.4 [0.4] years at baseline and 19.0 [0.7] years at follow-up). At 5-year follow-up, cannabis use (from 0 to )40 uses)was negatively associated with thickness in left prefrontal (peak: t785 = –4.87, cluster size = 1558 vertices; P = 1.10 × 10−6, random field theory cluster corrected) and right prefrontal (peak: t785 = –4.27, cluster size = 1551 vertices; P = 2.81 × 10−5, random field theory cluster corrected) cortices. Therewere no significant associations between lifetime cannabis use at 5-year follow-up and baseline cortical thickness, suggesting that the observed neuroanatomical differences did not precede initiation of cannabis use. Longitudinal analysis revealed that age-related cortical thinningwas qualified by cannabis use in a dose-dependent fashion such that greater use, from baseline to follow-up, was associated with increased thinning in left prefrontal (peak: t815.27 = –4.24, cluster size = 3643 vertices; P = 2.28 × 10−8, random field theory cluster corrected) and right prefrontal (peak: t813.30 = –4.71, cluster size = 2675 vertices; P = 3.72 × 10−8, random field theory cluster corrected) cortices. The spatial pattern of cannabis-related thinningwas associated with age-related thinning in this sample (r = 0.540; P ( .001), and a positron emission tomography–assessed cannabinoid 1 receptor–binding map derived from a separate sample of participants (r = −0.189; P ( .001). Analysis revealed that thinning in right prefrontal cortices, from baseline to follow-up,was associated with attentional impulsiveness at follow-up. CONCLUSIONS AND RELEVANCE Results suggest that cannabis use during adolescence is associated with altered eurodevelopment, particularly in cortices rich in cannabinoid 1 receptors and undergoing the greatest age-related thickness change in middle to late adolescence. |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Albaugh, M., Ottino-Gonzalez, J., Sidwell, A., Lepage, C., Juliano, A., Owens, M. M., Chaarani, B., Spechler, P., Fontaine, N., Rioux, P., Lewis, L., Jeon, S., Evans, A., D'Souza, D., Radhakrishnan, R., Banaschewski, T., Bokde, A. L. W., Quinlan, E. B., Conrod, P., Desrivieres, S., & Ittermann, B. (2021). Association of cannabis use during adolescence with neurodevelopment. JAMA Psychiatry, 78(9), 1031–1040. https://doi.org/10.1001/jamapsychiatry.2021.1258