| Zugriffsnummer | 46473 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Evaluation of synergistic image registration for motion-corrected coronary NaF-PET-MR |
| Autor(in); Institution |
Mayer, Johannes; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Jin, Yining; not affiliated
Wurster, Thomas-Heinrich; Klinik für Kardiologie, Charité Campus Benjamin Franklin, Universitätsmedizin Berlin, Berlin, GERMANY
Makowski, Marcus R.; Department of Radiology, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Kolbitsch, Christoph; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
|
| Quelle/Jahr | Philosophical Transactions of the Royal Society of London A: 379 (2021), 2200, 12 S. |
| Artikelnummer | 20200202 |
| ISSN | 1364-503X (PRINT) ; 1471-2962 (ONLINE) |
| DOI | |
| Verlag | London: The Royal Society |
| Freie Schlagworte | synergistic image registration ; cardiac motion ; respiratory motion ; motion-corrected image reconstruction ; PET-MR ; NaF-PET |
| Zusammenfassung | 1. Introduction Coronary artery disease (CAD) is one of the most common cardiovascular diseases. It can lead to heart failure, myocardial infarction and even sudden cardiac death. CAD is caused by a build-up of plaques in the coronary arteries which impair the blood supply of the heart. Previous studies have shown that the composition of these plaques could be an important diagnostic parameter to predict the progression of the disease and hence could be used to optimize patient treatment. NaF-PET has been shown to be a promising clinical imaging modality to visualize vulnerable plaques, i.e. likely to rupture and to trigger a cardiac event. Nevertheless, imaging the coronary arteries with PET is very challenging, because the heart is moving due to the heartbeat and respiratory motion during data acquisition. NaF uptake in the micro-calcification is very small and hence the physiological motion can lead to strong blurring of the uptake and make an accurate diagnosis challenging. Simultaneous PET-MR has been proposed to improve the quality of cardiac PET by using respiratory and/or cardiac motion information estimated from MR images for motion correction. Commonly, only MR information is used for motion estimation due to its excellent soft tissue contrast. Nevertheless, recent studies have shown that respiratory and cardiac motion estimation can be improved by combining motion-resolved MR and PET images for image registration for cardiac FDG-PET-MR. Improved motion estimation then leads to better image quality of the final motion-corrected PET data. So far, the advantages of synergistic image registration have only been shown for images with tracer uptake in the myocardium, i.e. a very large volume. In this paper, we evaluate if combining motion-resolved MR and NaF-PET image data also allows for a more accurate estimation of cardiac and respiratory motion of coronary plaques. The aim of this work is not to obtain the optimal image registration parameters but to investigate if synergistic NaF-PET-MR image registration is advantageous. This synergistic motion estimation approach is evaluated in simulated simultaneous NaF-PET-MR data and then applied to patients with calcified coronary plaques. The numerical simulations allowed for the evaluation of the accuracy of the obtained motion fields by comparing them to the ground truth motion information. In patients, the improvement of motion estimation and subsequent motion correction were evaluated visually. |
| Kostenfreier Zugang | Open Access Hybrid |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Mayer, J., Jin, Y., Wurster, T.-H., Makowski, M. R., & Kolbitsch, C. (2021). Evaluation of synergistic image registration for motion-corrected coronary NaF-PET-MR. Philosophical Transactions of the Royal Society of London A, 379(2200), 12 S. https://doi.org/10.1098/rsta.2020.0202