| Zugriffsnummer | 45816 |
| Dokumenttyp | Konferenzartikel in Zeitschrift |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Challenges in dosimetry of particle beams with ultra-high pulse dose rates |
| Autor(in); Institution |
Romano, F.; Istituto Nazionale di Fisica Nucleare, Sezione di Catania, Catania, ITALY; National Physical Laboratory (NPL), CMES - Medical Radiation Science, Teddington, UK
Subiel, A.; National Physical Laboratory (NPL), CMES - Medical Radiation Science, Teddington, UK
McManus, M.; National Physical Laboratory (NPL), CMES - Medical Radiation Science, Teddington, UK
Lee, N. D.; National Physical Laboratory (NPL), CMES - Medical Radiation Science, Teddington, UK
Palmans, H.; National Physical Laboratory (NPL), CMES - Medical Radiation Science, Teddington, UK; Medical Physics Group, EBG MedAustron GmbH, Wiener Neustadt, AUSTRIA
Thomas, R.; National Physical Laboratory (NPL), CMES - Medical Radiation Science, Teddington, UK
McCallum, S.; National Physical Laboratory (NPL), CMES - Medical Radiation Science, Teddington, UK; Queen's University Belfast, Centre for Plasma Physics, Belfast, IRELAND
Milluzzo, G.; Queen's University Belfast, Centre for Plasma Physics, Belfast, IRELAND
Borghesi, M.; Queen's University Belfast, Centre for Plasma Physics, Belfast, IRELAND
McIlvenny, A.; Queen's University Belfast, Centre for Plasma Physics, Belfast, IRELAND
Ahmed, H.; Queen's University Belfast, Centre for Plasma Physics, Belfast, IRELAND
Farabolini, W.; CERN, Geneva, SWITZERLAND
Gilardi, A.; CERN, Geneva, SWITZERLAND
Schüller, Andreas; 6.2, Dosimetrie für Strahlentherapie und Röntgendiagnostik, PTB-Braunschweig
|
| Quelle/Jahr | Journal of Physics: Conference Series: 1662 (2020), 1 - 5 |
| Artikelnummer | 012028 |
| ISSN | 1742-6588 (PRINT) ; 1742-6596 (ONLINE) |
| DOI | |
| Verlag | Bristol: IOP Publishing |
| Konferenzangaben | Micro-Mini & Nano Dosimetry and Innovative Technologies in Radiation Oncology (MMND ITRO 2020), Wollongong, 10-16, February, 2020, Australia |
| Zusammenfassung | Recent results from pre-clinical studies investigating the so-called FLASH effect suggest that the ultrahigh pulse dose rates (UHPDR) of this modality reduces normal tissue damage whilst preserving tumour response, when compared with conventional radiotherapy (RT). FLASH-RT is characterized by average dose rates of dozens of Gy/s instead of only a few Gy/min. For some studies, dose rates exceeding hundreds of Gy/s have been used for investigating the tissue response. Moreover, depending on the source of radiation, pulsed beams can be used with low repetition rate and large doses per pulse. Accurate dosimetry of high dose-rate particle beams is challenging and requires the development of novel dosimetric approaches, complementary to the ones used for conventional radiotherapy. The European Joint Research Project "UHDpulse" will develop a measurement framework, encompassing reference standards traceable to SI units and validated reference methods for dose measurements with UHPDR beams. In this paper, the UHDpulse project will be presented, discussing the dosimetric challenges and showing some first results obtained in experimental campaigns with pulsed electron beams and laser-driven proton beams. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 3.0 ; Creative Commons Attribution 3.0 License |
Zitierung
Romano, F., Subiel, A., McManus, M., Lee, N. D., Palmans, H., Thomas, R., McCallum, S., Milluzzo, G., Borghesi, M., McIlvenny, A., Ahmed, H., Farabolini, W., Gilardi, A., & Schüller, A. (2020). Challenges in dosimetry of particle beams with ultra-high pulse dose rates. Journal of Physics: Conference Series, 1662, 1–5. https://doi.org/10.1088/1742-6596/1662/1/012028