| Zugriffsnummer | 45706 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Novel benchtop magnetic particle spectrometer for process monitoring of magnetic nanoparticle synthesis |
| Autor(in); Institution |
Löwa, Norbert; 8.2, Biosignale, PTB-Berlin
Gutkelch, Dirk; 8.2, Biosignale, PTB-Berlin
Welge, Ernst-Albrecht; 8.2, Biosignale, PTB-Berlin
Welz, R.; Postnova Analytics GmbH, Landsberg am Lech, GERMANY
Meier, F.; Postnova Analytics GmbH, Landsberg am Lech, GERMANY
Baki, A.; Fraunhofer Institut für Mikrotechnik und Mikrosysteme IMM, Mainz, GERMANY
Bleul, R.; Fraunhofer Institut für Mikrotechnik und Mikrosysteme IMM, Mainz, GERMANY
Klein, T.; Postnova Analytics GmbH, Landsberg am Lech, GERMANY
Wiekhorst, Frank; 8.2, Biosignale, PTB-Berlin
|
| Quelle/Jahr | Nanomaterials: 10 (2020), 11, 15 S. |
| Artikelnummer | 2277 |
| Availability | [online only] |
| ISSN | 2079-4991 |
| DOI | |
| Verlag | Basel: MDPI |
| Freie Schlagworte | biomedical applications ; magnetic characterization ; magnetic nanoparticles ; magnetic particle spectroscopy ; process monitoring ; synthesis |
| Zusammenfassung | Magnetic nanoparticles combine unique magnetic properties that can be used in a variety of biomedical applications for therapy and diagnostics. These applications place high demands on the magnetic properties of nanoparticles. Thus, research, development, and quality assurance of magnetic nanoparticles requires powerful analytical methods that are capable of detecting relevant structural and, above all, magnetic parameters. By directly coupling nanoparticle synthesis with magnetic detectors, relevant nanoparticle properties can be obtained and evaluated, and adjustments can be made to the manufacturing process in real time. This work presents a sensitive and fast magnetic detector for online characterization of magnetic nanoparticles during their continuous micromixer synthesis. The detector is based on the measurement of the nonlinear dynamic magnetic response of magnetic nanoparticles exposed to an oscillating excitation at a frequency of 25 kHz, a technique also known as magnetic particle spectroscopy. Our results underline the excellent suitability of the developed magnetic online detection for coupling with magnetic nanoparticle synthesis based on the micromixer approach. The proven practicability and reliability of the detector for process monitoring forms the basis for further application fields, e.g., as a monitoring tool for chromatographic separation processes |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Löwa, N., Gutkelch, D., Welge, E.-A., Welz, R., Meier, F., Baki, A., Bleul, R., Klein, T., & Wiekhorst, F. (2020). Novel benchtop magnetic particle spectrometer for process monitoring of magnetic nanoparticle synthesis. Nanomaterials, 10(11), 15 S. https://doi.org/10.3390/nano10112277